黑色酵母金黄色葡萄球菌产生丰富的可溶性β-1,3-1,6-葡聚糖-一种具有已知健康益处的功能性食品成分。用作食品材料，可溶性β-1,3-1,6-葡聚糖通过使用蔗糖作为碳源的发酵生产。已经报道了β-1,3-1,6-葡聚糖的各种官能团，包括它的免疫调节作用,特别是在肠道中。它还具有抗肿瘤和抗转移作用，缓解流感和食物过敏，缓解压力.此外，它通过保护肠粘膜降低生活方式相关疾病的风险，减少脂肪,降低餐后血糖，促进骨骼健康，和治愈胃溃疡。此外，它诱导热休克蛋白70。临床研究报道了β-1,3-1,6-葡聚糖的抗过敏和降低甘油三酯的作用，这是生活方式相关疾病改善的指标。已经阐明了β-1,3-1,6-葡聚糖的一级和高级结构。具体来说,其在具有1,3-β键的葡萄糖主链上包含具有β-1,6键(70%或更多)的单个高度支化的葡萄糖残基。β-葡聚糖呈三螺旋结构,并积极进行了将其用作药物递送系统的研究。β-葡聚糖与抗炎物质或富勒烯的组合可用于靶向巨噬细胞。基于它的健康功能，β-1,3-1,6-葡聚糖是一种有趣的食品和药物材料。
The black yeast
Aureobasidium pullulans produces abundant soluble β-1,3-1,6-glucan-a functional food ingredient with known health benefits. For use as a food material, soluble β-1,3-1,6-glucan is produced via fermentation using sucrose as the carbon source. Various functionalities of β-1,3-1,6-glucan have been reported, including its immunomodulatory effect, particularly in the intestine. It also exhibits antitumor and antimetastatic effects, alleviates influenza and food allergies, and relieves stress. Moreover, it reduces the risk of lifestyle-related diseases by protecting the intestinal mucosa, reducing fat, lowering postprandial blood glucose, promoting bone health, and healing gastric ulcers. Furthermore, it induces heat shock protein 70. Clinical studies have reported the antiallergic and triglyceride-reducing effects of β-1,3-1,6-glucan, which are indicators of improvement in lifestyle-related diseases. The primary and higher-order structures of β-1,3-1,6-glucan have been elucidated. Specifically, it comprises a single highly-branched glucose residue with the β-1,6 bond (70% or more) on a backbone of glucose with 1,3-β bonds. β-Glucan shows a triple helical structure, and studies on its use as a drug delivery system have been actively conducted. β-Glucan in combination with anti-inflammatory substances or fullerenes can be used to target macrophages. Based on its health functionality, β-1,3-1,6-glucan is an interesting material as both food and medicine.
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