■抗治疗的听觉言语幻觉(TRAVHs)可能会导致暴力风险增加,自杀,和住院精神分裂症患者(SCZ)。尽管神经影像学研究已经确定了与AVH症状的神经相关性,特别是在TRAVH患者中相关的功能性脑活动仍然有限。功能近红外光谱(fNIRS)是一种便携式和合适的测量,特别是在相关任务期间探索大脑激活。因此,我们的研究人员旨在探讨SCZ-TRAVH脑血流动力学功能的差异,无AVH的精神分裂症患者(SCZ-nAVH),和健康对照(HCs),检查更具体地与TRAVH相关的神经异常。
■使用52通道功能性近红外光谱系统监测SCZ-TRAVH患者的血液动力学变化(n=38),SCZ-nAVH患者(n=35),和HC(n=30)在口头流利的任务(VFT)。VFT性能,临床病史,并注意到症状严重程度.使用MATLAB分析原始fNIRS数据以获得β值(VFT任务期间的大脑皮层活动响应);这些用于计算Δβ(VFTβ减去基线β),这代表了由VFT任务引起的氧合血红蛋白的变化程度。
■我们的结果表明,在26个通道(ch4,ch13-15,18,22,ch25-29,32,ch35-39,ch43-51,F=1.70至19.10,p<0.043,FDR校正),三组之间的Δβ值存在显着差异。进一步的成对比较显示,SCZ组(SCZ-TRAVH和/或SCZ-nAVH)的24个通道(ch13-15、18、22、25、ch26-29、ch35-39、ch43-49、ch50-51)的Δβ值明显低于HC组(p<0.026,FDR校正)。此外,右中央后回ch22异常激活相关,反过来,严重的TRAVH。
■我们的研究结果表明,前额叶皮层的特定区域可能与TRAVH有关,这可能对精神病的早期干预有影响。
UNASSIGNED: Treatment-resistant auditory verbal hallucinations (TRAVHs) might cause an increased risk of violence, suicide, and hospitalization in patients with schizophrenia (SCZ). Although neuroimaging studies have identified the neural correlation to the symptom of AVH, functional brain activity that correlates particularly in patients with TRAVH remains limited. Functional near-infrared spectroscopy (fNIRS) is a portable and suitable measurement, particularly in exploring brain activation during related tasks. Hence, our researchers aimed to explore the differences in the cerebral hemodynamic function in SCZ-TRAVH, patients with schizophrenia without AVH (SCZ-nAVH), and healthy controls (HCs), to examine neural abnormalities associated more specifically with TRAVH.
UNASSIGNED: A 52-channel functional near-infrared spectroscopy system was used to monitor hemodynamic changes in patients with SCZ-TRAVH (n = 38), patients with SCZ-nAVH (n = 35), and HC (n = 30) during a verbal fluency task (VFT). VFT performance, clinical history, and symptom severity were also noted. The original fNIRS data were analyzed using MATLAB to obtain the β values (the brain cortical activity response during the VFT task period); these were used to calculate Δβ (VFT β minus baseline β), which represents the degree of change in oxygenated hemoglobin caused by VFT task.
UNASSIGNED: Our results showed that there were significant differences in Δβ values among the three groups at 26 channels (ch4, ch13-15, 18, 22, ch25-29, 32, ch35-39, ch43-51, F = 1.70 to 19.10, p < 0.043, FDR-corrected) distributed over the prefrontal-temporal cortical regions. The further pairwise comparisons showed that the Δβ values of 24 channels (ch13-15, 18, 22, 25, ch26-29, ch35-39, ch43-49, ch50-51) were significantly lower in the SCZ group (SCZ-TRAVH and/or SCZ-nAVH) than in the HC group (p < 0.026, FDR-corrected). Additionally, the abnormal activation in the ch22 of right postcentral gyrus was correlated, in turn, with severity of TRAVH.
UNASSIGNED: Our findings indicate that specific regions of the prefrontal cortex may be associated with TRAVH, which may have implications for early intervention for psychosis.