背景:糖尿病(DM)是主要的公共卫生问题。这项研究旨在确定频率,模式,在索马里唯一的糖尿病门诊诊所中,2型糖尿病(T2DM)成人血脂异常的潜在决定因素。
方法:在2020年1月至2020年6月期间在我们的门诊就诊的5129名连续T2DM患者被纳入这项基于医院的横断面研究。参与者的人口统计特征,包括脂质面板,是从注册表系统中提取的。对血脂谱与相关参数进行相关性分析。使用多变量二元逻辑回归模型来确定血脂异常的独立决定因素以进行进一步分析。
结果:总体人口的平均年龄为51.9±12.2岁,男性177人(33.5%)。总血脂异常和动脉粥样硬化血脂异常分别为92.8%和24.8%,分别。血脂异常最常见的分离模式是高非高密度脂蛋白胆固醇(非HDL-C)(82.8%),其次是低密度脂蛋白胆固醇(LDL-C)(72.6%),高总胆固醇(TC)(54.3%),和低HDL-C(48.3%)。发现女性的高TC患病率较高(63.4%vs.54.2%,p=0.043)和更低的HDL-C(57.4%vs.46.3%,p=0.016)。高LDL-C和低HDL-C是复合型血脂异常中最常见的模式(18.1%),其次是高LDL-C和高甘油三酯(TG)(17.8%),以及低TG和低HDL-C(3.6%)。女性高LDL-C和低HDL-C的比例高于男性(20.3%vs.13.6%,p=0.036)。年龄,性别,身体质量指数,中心性肥胖,斑点尿蛋白尿,空腹血糖,血糖控制不佳,肌酐,在多因素logistic回归分析中,Hs-CRP和Hs-CRP均与不同的血脂异常模式相关.
结论:我们发现血脂异常的患病率,尤其是动脉粥样硬化模式,在索马里T2DM患者中非常高。加强卫生政策应该,因此,被建立来检测,治疗和预防血脂异常。
BACKGROUND: Diabetes mellitus (DM) is a major public health concern. This
study aims to determine frequency, pattern, and potential determinants of dyslipidemia among adults with type 2 DM (T2DM) at Somalia\'s only diabetes outpatient clinic.
METHODS: Five hundred twenty-nine consecutive patients with T2DM who applied to our outpatient clinic between January 2020 and June 2020 were included in this cross-sectional hospital-based
study. Demographic characteristics of participants, including lipid panel, were extracted from the registry system. Correlation analysis was performed between lipid profile and related parameters. Multivariate binary logistic regression models were used to identify independent determinants of dyslipidemia for further analysis.
RESULTS: The overall population\'s mean age was 51.9 ± 12.2 years, with 177 (33.5%) males. Total and atherogenic dyslipidemias were found in 92.8% and 24.8%, respectively. The most common isolated pattern of dyslipidemia was high non-high-density lipoprotein cholesterol (non-HDL-C) (82.8%), followed by high low-density lipoprotein cholesterol (LDL-C) (72.6%), high total cholesterol (TC) (54.3%), and low HDL-C (48.3%). Females were found to have a higher prevalence of high TC (63.4% vs. 54.2%, p = 0.043) and lower HDL-C (57.4% vs. 46.3%, p = 0.016). High LDL-C with low HDL-C was the most common pattern among combined type dyslipidemias (18.1%), followed by high LDL-C with high triglyceride (TG) (17.8%), as well as low TG with low HDL-C (3.6%). Females had a higher proportion of high LDL-C with low HDL-C than males (20.3% vs. 13.6%, p = 0.036). Age, gender, body mass index, central obesity, spot urinary proteinuria, fasting blood glucose, poor glycemic control, creatinine, and Hs-CRP were all associated with different dyslipidemia patterns in multivariate logistic regression analyses.
CONCLUSIONS: We found that the prevalence of dyslipidemia, especially atherogenic patterns, was extremely high among Somali T2DM patients. An enhanced health policy should, therefore, be established to detect, treat and prevent dyslipidemia.