■由于严重急性呼吸道综合症冠状病毒-2(SARS-CoV-2)引起的2019年冠状病毒病(COVID-19)可以表现为无症状的携带者状态或急性呼吸道疾病,有或没有严重的肺炎。无症状携带者对牙科行业来说是一个挑战,因为感染可能通过携带病毒的方式传播,和唾液在牙科环境中通过气溶胶生成程序(AGPS)。本综述的目的是对无症状个体唾液中的SARS-CoV-2进行系统评价。
■PubMed,谷歌学者,和MedRxiv数据库之间进行了搜索,并对现有数据进行了系统评价和荟萃分析,以评估SARS-CoV-2无症状携带者唾液中的病毒负担。纳入研究的所有研究人员都使用qRT-PCR检测SARS-CoV-2,并产生与病毒载量有关的定量数据(Ct值)。
■总共发现了322条英文文献记录,最终分析中纳入了8项研究,其中2642例SARS-CoV-2阳性和无症状个体。其中,16.7%(95%CI:11-23%)的SARS-CoV-2阳性唾液样本与13.1%(95%CI:12-17%)的呼吸道标本(鼻咽或鼻咽拭子)相比。
■因为大约有1/5到1/10的无症状个体在唾液或呼吸道分泌物中携带SARS-CoV-2,我们的结果强调了继续保持警惕的必要性和保持严格的至关重要性,在可预见的未来增加感染控制方案,以减轻COVID-19在牙科传播的潜在风险。
UNASSIGNED: The coronavirus disease 2019 (COVID-19) due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can present either as an asymptomatic carrier state or an acute respiratory disease, with or without severe pneumonia. The asymptomatic carriers are a challenge for the dental profession as the infection could be transmitted via virus-laden, and saliva in dental settings through aerosol-generating procedures (AGPSs). The aim of this
review was to perform a systematic
review of SARS-CoV-2 in the saliva of asymptomatic individuals.
UNASSIGNED: PubMed, Google scholar, and MedRxiv databases were searched between and a systematic
review and meta-analysis of the available data were performed to assess the viral burden in the saliva of asymptomatic carriers of SARS-CoV-2. All investigators of the included studies used qRT-PCR to detect SARS-CoV-2 and yield quantitative data (the Ct values) appertaining to the viral load.
UNASSIGNED: A total of 322 records in the English literature were identified, and eight studies with 2642 SARS-CoV-2-positive and asymptomatic individuals were included in the final analysis. Of these, 16.7% (95% CI: 11-23%) yielded SARS-CoV-2-positive saliva samples in comparison to 13.1% (95% CI: 12-17%) of the respiratory specimens (nasopharyngeal or nose-throat swabs).
UNASSIGNED: As approximately 1 in 5 to 1 in 10 asymptomatic individuals harbour SARS-CoV-2 in either saliva or respiratory secretions, our results highlight the need for continued vigilance and the critical importance of maintaining strict, additional infection control regimens for the foreseeable future to mitigate the potential risks of COVID-19 transmission in dentistry.