Articaine

阿替卡因
  • 文章类型: Review
    强直性肌营养不良(肌营养不良症;DM)是一种罕见的进行性遗传性肌肉疾病,在出生时可表现出不同的严重程度,在儿童早期,或者最常见的是成年人。DM患者,特别是类型1(DM1),对镇静催眠药的呼吸抑制作用极其敏感,抗焦虑药,和阿片类激动剂。该病例报告描述了一名37岁的男性患者,先前未诊断为DM1,他在使用静脉注射咪达唑仑的最低程度镇静下接受了牙科护理。在案件中,患者经历了2次短暂的低氧血症发作,其中第二种需要在丙泊酚和琥珀酰胆碱之后进行紧急插管,并导致住院时间延长.在最后一次局部麻醉剂注射后大约2小时,由于轻微的ST升高和怀疑局部麻醉剂毒性(LAST),给予脂质乳剂(LiposynII20%)输注。治疗后几个月,病人跌倒导致致命的创伤性脑损伤。在此病例报告中指出的并发症主要归因于DM1的未知诊断,尽管可能存在其他诱发因素。本报告还提供了对强直性肌营养不良患者进行局部麻醉牙科护理的文献和临床指南的基本回顾。镇静,或全身麻醉。
    Myotonic dystrophy (dystrophia myotonica; DM) is an uncommon progressive hereditary muscle disorder that can present with variable severity at birth, in early childhood, or most commonly as an adult. Patients with DM, especially type 1 (DM1), are extremely sensitive to the respiratory depressant effects of sedative-hypnotics, anxiolytics, and opioid agonists. This case report describes a 37-year-old male patient with previously undiagnosed DM1 who received dental care under minimal sedation using intravenous midazolam. During the case, the patient experienced 2 brief episodes of hypoxemia, the second of which required emergency intubation after propofol and succinylcholine and resulted in extended hospital admission. A lipid emulsion (Liposyn II 20%) infusion was given approximately 2 hours after the last local anesthetic injection due to slight ST elevation and suspicion of local anesthetic toxicity (LAST). Months after treatment, the patient suffered a fall resulting in a fatal traumatic brain injury. Complications noted in this case report were primarily attributed to the unknown diagnosis of DM1, although additional precipitating factors were likely present. This report also provides a basic review of the literature and clinical guidelines for managing myotonic dystrophy patients for dental care with local anesthesia, sedation, or general anesthesia.
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  • 文章类型: Case Reports
    BACKGROUND: Allergy to lidocaine is extremely rare but if it occurs, one should switch to an alternative drug and discontinue the use of lidocaine so that adverse consequences do not occur.
    METHODS: We present the case of a 70 year old male patient who had come to our department to undergo extraction of his decayed teeth under local anesthesia.
    CONCLUSIONS: He had history of allergy to lidocaine. Type IV hypersensitivity to lidocaine was confirmed by positive skin prick testing to the drug. Skin prick testing was also performed for articaine that was available with us, and the test was found to be negative without any wheal or flare reaction even after 72 h. Thus it was confirmed that he was non-allergic to articaine and successfully underwent exodontia by using the same.
    CONCLUSIONS: Articaine can be a suitable alternative in patients with true lignocaine allergy and vice-versa. No cross-reactivity has been reported between lidocaine and articaine so far. However, the number of cases reported in the past are limited, hence more cases are required in the future to prove its authenticity.
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  • 文章类型: Journal Article
    OBJECTIVE: Local anaesthesia is the standard of care during dental extractions. With the advent of newer local anesthetic agents, it is often difficult for the clinician to decide which agent would be most efficacious in a given clinical scenario. This study assessed the efficacy of equal-milligram doses of lidocaine and articaine in achieving surgical anaesthesia of maxillary posterior teeth diagnosed with irreversible pulpitis.
    METHODS: This case-series evaluated a total of 41 patients diagnosed with irreversible pulpitis in a maxillary posterior tooth. Patients randomly received an infiltration of either 3.6 mL (72 mg) 2% lidocaine with 1:100,000 epinephrine or 1.8 mL (72 mg) 4% articaine with 1:100,000 epinephrine in the buccal fold and palatal soft tissue adjacent to the tooth. After 10 minutes, initial anaesthesia of the tooth was assessed by introducing a sterile 27-gauge needle into the gingival tissue adjacent to the tooth, followed by relief of the gingival cuff. Successful treatment was considered to have occurred when the tooth was extracted with no reported pain. Data was analyzed with the Fisher\'s exact test, unpaired t-test and normality test.
    RESULTS: Twenty-one patients received lidocaine and 20 received articaine. Forty of the 41 patients achieved initial anaesthesia 10 minutes after injection: 21 after lidocaine and 19 after articaine (P = 0.488). Pain-free extraction was accomplished in 33 patients: 19 after lidocaine and 14 after articaine buccal and palatal infiltrations (P = 0.226).
    CONCLUSIONS: There was no significant difference in efficacy between equivalent doses of lidocaine and articaine in the anaesthesia of maxillary posterior teeth with irreversible pulpitis.
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