由于它们在解剖学上的相似性,生理学,和人类的药理学,小鼠是一个有价值的模型系统,研究的产生和机制调节常规流出阻力,从而眼内压。此外,小鼠模型对于理解导致高眼压的常规流出体内平衡和功能障碍的复杂性至关重要。在这次审查中,我们描述了一套发展的最低可接受标准,表征,并利用开角型高眼压小鼠模型。我们预计,这套标准做法将在使用小鼠模型时提高科学的严谨性,并使研究人员能够更好地复制和建立以前的发现。
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.