■视神经脊髓炎谱系障碍(NMOSD)是一个相对较新的术语,包括患有视神经脊髓炎(NMO)和相关免疫疾病的患者。这种情况的诊断需要血清阳性的水通道蛋白-4免疫球蛋白G(AQP-4IgG),存在至少一个核心临床特征和排除替代诊断。在撒哈拉以南非洲报告的病例很少。
■本文的目的是报告一个典型的NMOSD病例,AQP-4IgG血清阳性和正常的大脑,颈部和胸部MRI表现。
■我们报告了一名25岁的尼日利亚妇女,她反复出现和交替出现的虚弱,四肢疼痛和麻木,伴有阵发性疼痛的左侧强直痉挛和尿失禁。她之前有反复发作的症状,两只眼睛都出现了偶发性和交替性的视力丧失,与眼部疼痛有关。检查结果显示精神状态完好无损,没有颅神经缺损和局灶性肢体无力。右侧深层肌腱反射被夸大。生命体征在正常范围内。脑部核磁共振,颈椎MRI和胸椎MRI均显示正常。血清水通道蛋白-4IgG测定返回阳性,滴度为1:32。她开始服用高剂量类固醇,症状逐渐改善。
■这些发现证实了视神经脊髓炎谱系障碍的诊断,并满足国际NMO诊断小组(IPND)于2015年发布的诊断标准。
UNASSIGNED: Neuromyelitis optica spectrum disorder (NMOSD) is a relatively new terminology composed to encompass patients with neuromyelitis optica (NMO) and related immunological conditions. The diagnosis of this condition requires a seropositive
aquaporin-4 immunoglobulin G (AQP-4 IgG), the presence of at least one core clinical characteristic and the exclusion of alternative diagnoses. Very few cases have been reported in sub-Saharan Africa.
UNASSIGNED: The aim of this article is to report a classical
case of NMOSD with AQP-4 IgG seropositivity and normal brain, cervical and thoracic MRI findings.
UNASSIGNED: We report a 25-year-old Nigerian woman who presented with recurrent and alternating weakness, pain and numbness of all limbs, associated with episodic painful left-sided tonic spasms and urinary incontinence. She had earlier had symptoms of recurrent, episodic and alternating loss of vision in both eyes, associated with ocular pain.Examination findings revealed an intact mental status, no cranial nerve deficit and no focal limb weakness. Right-sided deep tendon reflexes were exaggerated. Vital signs were within normal limits. Brain MRI, Cervical spine MRI and Thoracic spine MRI all revealed normal findings. Serum
aquaporin-4 IgG assay returned positive with a titer of 1:32.She was commenced on high dose steroids and there was gradual improvement of symptoms.
UNASSIGNED: These findings confirmed the diagnosis of neuromyelitis optica spectrum disorder, and satisfies the diagnostic criteria published in 2015 by the International Panel for NMO Diagnosis (IPND).