背景:红色蜂胶(RdProp)是由蜜蜂蜜蜂生产的树脂,它收集了植物来源表面的带红色的渗出物,Dalbergiaeastophylum,在巴西俗称“rabodebugo”。被认为是第13种巴西蜂胶,由于其天然成分,这种树脂越来越突出,富含其他类型蜂胶中未发现的生物活性物质。
目的:这篇综述旨在解决RdProp的最重要特征,它的植物起源,主要成分,其生物学特性和与该天然产品相关的专利。
方法:通过SciFinder,谷歌专利,Patus®和Spacenet,直到2017年8月,搜索了涉及“红色蜂胶”一词的科学文章和专利。
结果:许多生物学特性,包括抗菌药物,抗炎,抗寄生虫,抗肿瘤,抗氧化剂,代谢和营养活动归因于RdProp,证明了它在食品中的巨大潜力,制药和化妆品行业。
结论:可用的论文与RdProp的药理潜力有关,但是,导致每种活性的分子机制或生物活性化合物尚未完全阐明。目前发现的RdProp专利是针对制药工业的组件(EP2070543A1;WO2014186851A1;FR3006589A1;CN1775277A;CN105797149A;CN1879859A),化妆品(JP6012138B2;JP2008247830A;JP6012138B2)和食品(JP5478392B2;CN101380052A;WO2006038690A1)。
BACKGROUND: The red propolis (RdProp) is a resin produced by Apis mellifera bees, which collect the reddish exudate on the surface of its botanic source, the species Dalbergia ecastophyllum, popularly known in Brazil as \"rabo de bugio\". Considered as the 13th type of Brazilian propolis, this resin has been gaining prominence due to its natural composition, rich in bioactive substances not found in other types of propolis.
OBJECTIVE: This
review aims to address the most important characteristics of RdProp, its botanical origin, the main constituents, its biological properties and the patents related to this natural product.
METHODS: By means of the SciFinder, Google Patents, Patus® and Spacenet, scientific articles and patents involving the term \"red propolis\" were searched until August 2017.
RESULTS: A number of biological properties, including antimicrobial, anti-inflammatory, antiparasitic, antitumor, antioxidant, metabolic and nutraceutical activities are attributed to RdProp, demonstrating the great potential of its use in the food, pharmaceutical and cosmetics industries.
CONCLUSIONS: The available papers are associated to pharmacological potential of RdProp, but the molecular mechanisms or bioactive compounds responsible for each activity have not yet been fully elucidat ed. The RdProp patents currently found are directed to components for the pharmaceutical industry (EP2070543A1; WO2014186851A1; FR3006589A1; CN1775277A; CN105797149A; CN1879859A), cosmetic (JP6012138B2; JP2008247830A; JP6012138B2) and food (JP5478392B2; CN101380052A; WO2006038690A1).