冠周炎是一种常见疾病,在第三磨牙爆发期间会影响个体的生活质量。报告的主要临床体征和症状包括牙龈盖层的存在,疼痛,吞咽困难,和有功能损害的关口。本研究显示了一例使用抗菌光动力疗法(aPDT)治疗的冠周炎,使用新的亚甲基蓝口服制剂(INPIBR1020170253902)。一位女性患者,27岁,出现最初的冠周炎,有她的痛苦,张开嘴,和评估肿胀。她接受了无菌盐水冲洗和使用0.005%浓度的新MB进行光动力治疗的方案,并用低强度激光λ=660nm照射,每点9J,和318J/cm2的辐射暴露。在aPDT后第4天评估变量。疼痛改善100%,张口增加1,3cm。使用新的MB公式在aPDT之前和之后的水肿没有差异。尽管结果是基于单个病例报告,提出的假设是,使用新的MB配方的aPDT是治疗由冠周炎早期引起的疼痛和三联肌的有效疗法。需要进行良好的随机临床试验,以将这种新制剂与常规aPDT进行比较,以进一步推广结果。
Pericoronitis is a common disease that impacts the quality of life of individuals during the eruption of the third molars. Among the main clinical signs and symptoms reported were the presence of gingival operculum, pain, difficulty swallowing, and trismus with functional impairment. The present study shows a
case report of pericoronitis treated with antimicrobial photodynamic therapy (aPDT), using a new oral formulation (INPI BR 1020170253902) of methylene blue. A female patient, 27 years old, presenting initial pericoronitis, had her pain, mouth opening, and swelling evaluated. She was submitted to a protocol of irrigation with sterile saline and photodynamic therapy using the new MB at 0.005% concentration and irradiation with low-intensity laser λ = 660 nm, 9 J per point, and radiant exposure of 318 J/cm2. The variables were evaluated on 4th day after aPDT. There was a 100% improvement in pain and an increase of 1,3 cm in mouth opening. There was no difference in the edema before and after aPDT using the new MB formula. Although the results are based on a single
case report, suggest the hypothesis that aPDT using the new MB formula is an efficient therapy in the treatment of pain and trismus caused by the early stage of pericoronitis. Well-conducted randomized clinical trials are needed to compare this new formulation with conventional aPDT for further generalization of results.