光动力疗法(PDT)依赖于光敏染料的局部或全身给药,称为光敏剂,积累到目标部位,然后用适当波长和通量的光激发。该光活化分子与细胞内氧反应,通过产生活性氧来诱导靶细胞的选择性细胞毒性。肝细胞癌(HCC),全球癌症相关死亡率的主要原因之一,没有足够的治疗选择。在这次审查中,我们讨论了PDT的机制和优点及其作为抗癌疗法的最新进展。我们还强调了这种新疗法在诊断中的应用,可视化,和肝癌的治疗。我们研究潜在的挑战,一些临床前和临床研究,以及与PDT相关的未来研究的可能性。最后,我们讨论了通过PDT的主动免疫应答的机制,然后探讨了PDT在HCC的背景下产生抗肿瘤免疫应答的作用,重点是基于检查点抑制剂的免疫疗法。这篇综述的目的是提出PDT作为肝癌现有治疗的合理辅助治疗,强调肝癌治疗的可行组合方法。
Photodynamic Therapy (PDT) relies on local or systemic administration of a light-sensitive dye, called photosensitizer, to accumulate into the target site followed by excitation with light of appropriate wavelength and fluence. This photo-activated molecule reacts with the intracellular oxygen to induce selective cytotoxicity of targeted cells by the generation of reactive oxygen species. Hepatocellular carcinoma (HCC), one of the leading causes of cancer-associated mortality worldwide, has insufficient treatment options available. In this
review, we discuss the mechanism and merits of PDT along with its recent developments as an anti-cancerous therapy. We also highlight the application of this novel therapy for diagnosis, visualization, and treatment of HCC. We examine the underlying challenges, some pre-clinical and clinical studies, and possibilities of future studies associated with PDT. Finally, we discuss the mechanism of an active immune response by PDT and thereafter explored the role of PDT in the generation of anti-tumor immune response in the context of HCC, with an emphasis on checkpoint inhibitor-based immunotherapy. The objective of this
review is to propose PDT as a plausible adjuvant to existing therapies for HCC, highlighting a feasible combinatorial approach for HCC treatment.