目标:迄今为止,为了全面总结补充雄烯二酮的效果,尚未进行荟萃分析以从随机安慰剂对照试验(RCT)中收集证据.因此,这项研究的目的是对所有RCT进行系统评价和荟萃分析,探索雄烯二酮补充对个体激素的影响,脂质,和人体测量指数。
方法:我们搜索了五个数据库(WebofScience,Scopus,Embase,PubMed/MEDLINE,和GoogleScholar)使用医学主题词(MeSH)和非MeSH术语的组合。使用随机效应模型,我们将结局总结为加权平均差(WMD),95%置信区间(CI).
结果:8篇符合条件的文章被纳入荟萃分析。合并效应大小表明雄烯二酮补充对血清雌二醇浓度有显著影响(WMD:20.82ng/ml,95%CI:7.25至34.38,p=0.003),甘油三酯(TG,大规模杀伤性武器:-0.19毫克/分升,95%CI:-0.96,0.57,p=0.000),和高密度脂蛋白(HDL)-胆固醇(WMD:-0.13mg/dl,95%CI:-0.23至-0.03,p=0.009);然而,它对睾酮没有影响(WMD:0.098ng/ml,95%CI:-0.499至0.696,p=0.748),体重(大规模杀伤性武器:0.579公斤,95%CI:-4.02至5.17,p=0.805),体重指数(BMI,WMD:-0.73kg/m2,95%CI:-2.98,1.50,p=0.519),低密度脂蛋白(LDL)-胆固醇(WMD:-0.074mg/dl,95%CI:-0.37至0.22,p=0.622),和总胆固醇(TC,大规模杀伤性武器:-0.15mg/dl,95%CI:-0.49,0.17,p=0.198)。
结论:这些发现表明补充雄烯二酮可以降低TG和HDL-胆固醇并增加雌二醇浓度。
OBJECTIVE: To date, no meta-analysis has been carried out to collect evidence from randomized placebo-controlled trials (RCTs) for the purpose of comprehensively summarizing the effect of
androstenedione supplementation. Therefore, the aim of this research was to perform a systematic
review and meta-analysis of all RCTs that explored the effect of
androstenedione supplementation on individual hormonal, lipid, and anthropometric indices.
METHODS: We searched five databases (Web of Science, SCOPUS, Embase, PubMed/MEDLINE, and Google Scholar) using a combination of medical subject headings (MeSH) and non-MeSH terms. Using the random-effects model, we summarized the outcomes as weighted mean difference (WMD) with 95% confidence interval (CI).
RESULTS: Eight eligible articles were included in the meta-analysis. The pooled effect sizes suggested a significant effect of
androstenedione supplementation on serum estradiol concentrations (WMD: 20.82 ng/ml, 95% CI: 7.25 to 34.38, p = 0.003), triglycerides (TG, WMD: -0.19 mg/dl, 95% CI: - 0.96, 0.57, p = 0.000), and high-density lipoprotein (HDL)-cholesterol (WMD: - 0.13 mg/dl, 95% CI: - 0.23 to - 0.03, p = 0.009); however, it had no effect on testosterone (WMD: 0.098 ng/ml, 95% CI: - 0.499 to 0.696, p = 0.748), body weight (WMD: 0.579 kg, 95% CI: - 4.02 to 5.17, p = 0.805), body mass index (BMI, WMD: - 0.73 kg/m2, 95% CI: - 2.98, 1.50, p = 0.519), low-density lipoprotein (LDL)-cholesterol (WMD: - 0.074 mg/dl, 95% CI: - 0.37 to 0.22, p = 0.622), and total cholesterol (TC, WMD: - 0.15 mg/dl, 95% CI: - 0.49, 0.17, p = 0.198).
CONCLUSIONS: These findings indicate that
androstenedione supplementation can lower TG and HDL-cholesterol and increase estradiol concentrations.