研究发现特应性皮炎(AD)与各种合并症之间存在关联。
评估成人中AD与合并症之间关联的证据。
我们的多学科工作组对AD和选定的合并症之间的关联进行了系统评价。我们应用了建议分级,评估,发展,以及评估证据确定性的预后方法,根据现有证据提供关联声明。
对证据的分析得出32项陈述。明确的证据表明AD在成人中的关联和选择过敏,特应性,确定了免疫介导的心理健康和骨骼健康状况以及皮肤感染。有一些证据支持AD和物质使用之间的关联,注意缺陷多动障碍,和代谢综合征的元素。证据表明与各种心血管疾病有很小的关联。成人AD与自闭症谱系障碍之间的关联,心肌梗塞,中风,代谢综合征尚无定论。
此分析基于进行时的最佳可用证据。本指南未对成人AD合并疾病的筛查或管理提出建议。
临床医生应注意与AD相关的合并症。需要进一步的研究来确定筛查或治疗合并症是否对成人AD患者有益。
Studies found associations between atopic dermatitis (AD) and various comorbidities.
To appraise evidence of the association between AD and comorbidities among adults.
Our multidisciplinary work group conducted a systematic review of the association between AD and selected comorbidities. We applied the Grading of Recommendations, Assessment, Development, and Evaluation for prognosis approach for assessing the certainty of the evidence, providing statements of association based on the available evidence.
Analysis of the evidence resulted in 32 statements. Clear evidence of the association of AD in adults and select allergic, atopic, immune-mediated mental health and bone health conditions and skin infections was identified. There is some evidence supporting an association between AD and substance use, attention deficit hyperactivity disorder, and elements of metabolic syndrome. Evidence suggests a small association with various cardiovascular conditions. The association between AD in adults and autism spectrum disorders, myocardial infarction, stroke, and metabolic syndrome is inconclusive.
This analysis is based on the best available evidence at the time it was conducted. This
guideline does not make recommendations for screening or management of comorbidities in adults with AD.
Clinicians should be aware of comorbidities associated with AD. Further research is needed to determine whether screening or management of comorbidities is beneficial for adults with AD.