Alcoholic intoxication

酒精中毒
  • 文章类型: Journal Article
    Up to now, there is no adequate definition of the alcohol hangover. The purpose of the current study was to develop a useful definition, and consensus among those who will use it in scientific publications. A survey was conducted among N=1099 social drinkers who recently had a hangover. They were asked to provide their definition of the alcohol hangover. Text mining and content analysis revealed 3 potential definitions. These were submitted to members of the Alcohol Hangover Research Group, who were asked to give their expert opinion on the proposed definitions. Taking into account their comments and suggestions, the following definition for the alcohol hangover was formulated: \"The alcohol hangover refers to the combination of mental and physical symptoms, experienced the day after a single episode of heavy drinking, starting when blood alcohol concentration approaches zero.\"
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    文章类型: Journal Article
    荷兰全科医师实践指南“问题饮酒”包含(早期)认可的建议,问题饮酒的诊断和治疗,包括对年轻人的建议和急性酒精中毒的管理。在日常实践中,酒精问题主要表现为间接信号和特定症状。实践指南建议在无法直接解释症状的每种情况下询问酒精使用情况。全科医生通常能够自己治疗有饮酒问题的患者。全科医生和执业护士的短期干预措施可有效减少酒精使用。“电子心理健康”是一种可以用于诊断和治疗问题酒精使用的辅助手段。
    The Dutch College of General Practitioners\' practice guideline \"Problem drinking\" contains recommendations for the (early) recognition, diagnosis and treatment of problem drinking and includes recommendations for young people and the management of acute alcohol intoxication. In daily practice problems with alcohol manifest themselves mainly as indirect signals and aspecific symptoms. The practice guideline recommends asking about alcohol use in every case where symptoms cannot be directly explained. General practitioners are usually able treat patients with a drinking problem themselves. Short-term interventions by the general practitioner and practice nurse are effective in the reduction of alcohol use. \'E-mental health\' is an aid that can be used in the diagnosis and treatment of problem alcohol use.
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  • 文章类型: Letter
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    OBJECTIVE: Undergraduate students frequently exceed guideline limits for alcohol intake in a single session and are highly susceptible to associated health, social, and economic problems. Psychological theory suggests that interventions aimed at reducing alcohol consumption should target both motivational and volitional phases of action to be effective. This study reports an integrated theory-based intervention aimed at reducing undergraduates\' alcohol consumption in excess of guideline limits.
    METHODS: The study adopted a 2 (motivation: mental simulation vs. no mental simulation) × 2 (volitional: implementation intention vs. no implementation intention) randomized controlled design presented in an online format.
    METHODS: Undergraduate students (N= 238; females, n= 133, M age = 20.11, SD= 2.09; males, n= 105, M age = 20.38, SD= 1.35) completed baseline psychological measures and self-reported alcohol consumption as units consumed and heavy episodic drinking occasions followed by the intervention manipulation (if any). One month later participants completed follow-up measures of the psychological variables and alcohol consumption.
    RESULTS:  Significant reductions in alcohol consumption were observed at follow-up. Participants receiving a mental simulation intervention reported significantly fewer units of alcohol consumed and heavy episodic drinking occasions. Among participants with high baseline alcohol consumption, participants in the combined mental simulation and implementation intention intervention group consumed significantly fewer units than other groups.
    CONCLUSIONS: Results support the use of these theory-based strategies to reduce alcohol drinking in excess of guideline limits among undergraduates. There was preliminary support for the interaction between the two strategies among heavier drinkers. Targeting both motivational and implemental phases of action poses a high probability for success in changing alcohol-related behaviour in this population.
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  • 文章类型: Historical Article
    酒后驾车的历史和立法对策仍然是未知的。这一贡献追溯了1945年至1967年《道路安全法》之后英国的事态发展。第一部分着重于1950年代议会外压力小组的形成。对政府支持的《德鲁报告》(1959年)的影响进行了解释,以及格雷厄姆·佩奇在修辞和创造性地部署德鲁研究的方式,行人协会和欧内斯特·马普尔斯的主要发言人,保守党交通部长。最后一部分询问了导致引入呼吸分析仪的关键辩论。本文得出的结论是,1960年代英国迟来的道路安全立法的引入揭示了高度的跨党派共识。只有内政部的高级官员,在较小程度上,在交通运输部,一再威胁要推迟改革。
    The history of drink driving and legislative responses to it remain virtual terra incognita. This contribution traces developments in Britain between 1945 and the aftermath of the Road Safety Act in 1967. The first section focuses on the formation of an extra-parliamentary pressure group in the 1950s. This is complemented by an interpretation of the impact of the government-backed Drew Report (1959), and the ways in which Drew\'s research was rhetorically and creatively deployed by Graham Page, leading spokesman for the Pedestrians\' Association and Ernest Marples, the Conservative Minister of Transport. The final section interrogates key debates leading up to the introduction of the breathalyser. The article concludes that belated introduction of road safety legislation in Britain in the 1960s revealed a high degree of cross-party consensus. Only senior officials at the Home Office, and to a lesser extent, at the Ministry of Transport, repeatedly threatened to delay reform.
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  • 文章类型: Consensus Development Conference
    Alcohol-induced hangover, defined by a series of symptoms, is the most commonly reported consequence of excessive alcohol consumption. Alcohol hangovers contribute to workplace absenteeism, impaired job performance, reduced productivity, poor academic achievement, and may compromise potentially dangerous daily activities such as driving a car or operating heavy machinery. These socioeconomic consequences and health risks of alcohol hangover are much higher when compared to various common diseases and other health risk factors. Nevertheless, unlike alcohol intoxication the hangover has received very little scientific attention and studies have often yielded inconclusive results. Systematic research is important to increase our knowledge on alcohol hangover and its consequences. This consensus paper of the Alcohol Hangover Research Group discusses methodological issues that should be taken into account when performing future alcohol hangover research. Future research should aim to (1) further determine the pathology of alcohol hangover, (2) examine the role of genetics, (3) determine the economic costs of alcohol hangover, (4) examine sex and age differences, (5) develop common research tools and methodologies to study hangover effects, (6) focus on factor that aggravate hangover severity (e.g., congeners), and (7) develop effective hangover remedies.
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  • 文章类型: Journal Article
    背景:调查表明,超过“明智”酒精摄入量的准则是司空见惯的,改变人口摄入量对健康和社会的影响可能相当大。如果要成功实施公共卫生干预措施,首先重要的是确定这些行为的相关性,包括社会经济劣势。这就是本研究的目的。
    方法:来自苏格兰西部的576名男性的人口代表性队列研究。1988年收集了有关生命历程社会经济地位的数据(年龄约55岁)。1990/2年(大约59岁)确定了饮酒模式(详细的七天回忆)和问题饮酒(CAGE问卷)。计算了不平等的相对指数,以探索生命历程不同时期不同社会环境指标的比较强度。
    结果:早年和成年期的社会经济逆境与超过每周和每日饮酒指南的风险增加有关。成人社会经济地位指标显示出最强的关联。其中,成年期社会经济剥夺的物质指标-汽车拥有量,住房保有权-与大量饮酒和问题饮酒的关系比教育稍微更强烈,收入和职业社会阶层。早期生活剥夺对酒精摄入的影响很大一部分是通过成人社会经济地位介导的。当饮酒问题是人们感兴趣的结果时,类似的结果也很明显。
    结论:在该队列中的男性中,在整个生命周期中暴露于不利的社会环境,但尤其是在成年后,与有害的饮酒模式和中年后期饮酒问题有关。
    BACKGROUND: With surveys suggesting that exceeding guidelines for \'sensible\' alcohol intake is commonplace, the health and social impact of modifying intake on a population level is potentially considerable. If public health interventions are to be successfully implemented, it is first important to identify correlates of such behaviours, including socioeconomic disadvantage. This was the aim of the present study.
    METHODS: Population-representative cohort study of 576 men from the West of Scotland. Data on life course socioeconomic position were collected in 1988 (at around 55 years of age). Alcohol consumption patterns (detailed seven day recall) and problem drinking (CAGE questionnaire) were ascertained in 1990/2 (at around 59 years of age). A relative index of inequality was computed to explore the comparative strength of different indicators of social circumstances from different periods of the life course.
    RESULTS: Socioeconomic adversity in both early life and in adulthood was related to an increased risk of exceeding the weekly and daily alcohol guidelines, with adult indicators of socioeconomic position revealing the strongest associations. Of these, material indicators of socioeconomic deprivation in adulthood - car ownership, housing tenure - were marginally more strongly related to heavy alcohol intake and problem drinking than education, income and occupational social class. A substantial proportion of the influence of early life deprivation on alcohol intake was mediated via adult socioeconomic position. Similar results were apparent when problem drinking was the outcome of interest.
    CONCLUSIONS: In men in this cohort, exposure to disadvantaged social circumstances across the lifecourse, but particularly in adulthood, is associated with detrimental patterns of alcohol consumption and problem drinking in late middle age.
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  • 文章类型: Journal Article
    目的:这项研究评估了性别特异性的乙醇给药方案,该方案旨在产生两个峰值呼吸酒精浓度(BrAC)-0.07或0.10g/2101之一。评估了BrAC的受试者间和受试者内变异性,并评估了几种降低BrAC变异性的可能方法。
    方法:受试者(16名女性,16人,年龄21-30岁)在低(女性0.49克/千克,男性在10分钟内消耗0.53g/kg)和高(女性0.81g/kg,男性在20分钟内消耗0.89g/kg)乙醇剂量,在禁食4小时后消费。所有受试者都是定期饮酒者。
    结果:低剂量后实际达到的平均(+/-SD)峰值BrAC为0.069+/-0.011g/2101,和高剂量后0.105+/-0.014g/2101。峰值BrAC的平均值,两种剂量的BrAC达到峰值的时间和曲线下面积在性别之间均无统计学差异.在同等性别和体重调整剂量后,受试者之间的BrAC变化多达两倍。在男性中,乙醇药代动力学参数随剂量和时间的变化具有一定的可重复性,但不是女人。
    结论:所使用的剂量导致女性和男性在每个剂量下平均乙醇暴露量相等,平均峰值BrAC接近目标,但在乙醇药代动力学中,受试者间和受试者内存在显著差异。
    OBJECTIVE: This study evaluated gender-specific ethanol dosing protocols that were designed to result in one of two peak breath alcohol concentrations (BrACs)--0.07 or 0.10 g/2101. Inter- and intrasubject variability in BrAC were assessed and several possible methods for reducing variability in BrAC were evaluated.
    METHODS: Subjects (16 women, 16 men, ages 21-30 years) were studied after low (women 0.49 g/kg, men 0.53 g/kg consumed over 10 minutes) and high (women 0.81 g/kg, men 0.89 g/kg consumed over 20 minutes) ethanol doses, consumed following a 4-hour fast. All subjects were regular drinkers.
    RESULTS: Mean (+/-SD) peak BrACs actually achieved were 0.069+/-0.011 g/2101 after the low dose, and 0.105+/-0.014 g/2101 after the high dose. Mean values for peak BrAC, time to peak BrAC and area under the curve were not statistically significantly different between genders at either dose. BrACs varied by as much as twofold between subjects after equivalent gender and body weight adjusted doses. There was some reproducibility of ethanol pharmacokinetic parameters over dose and time in men, but not in women.
    CONCLUSIONS: The doses used resulted in equivalent mean ethanol exposures for women and men at each dose, with mean peak BrACs that closely approached the targets, but there was substantial inter- and intrasubject variability in ethanol pharmacokinetics.
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