背景:血管内肌皮细胞瘤是一种罕见类型的肌皮细胞瘤。在以前报道的大多数病例中,这些是良性的,发生在腿或脖子上,复发率低。我们已经描述了导致自发性深静脉血栓形成的血管内肌皮细胞瘤的独特病例。
■一名37岁男子表现为上臂突发性疼痛和肿胀;体格检查显示10厘米,明显的,公司,和上臂的移动病变。活检显示血管内肌皮细胞瘤;免疫组织学检查显示贵重静脉管腔有病变。肿瘤包含丰富的粘液样基质,梭形细胞在血管周围以同心的血管周围方式增殖。肿瘤细胞对CD34和平滑肌肌动蛋白染色为阳性。
■患者在局部麻醉下接受了肿块的完全切除;此后没有观察到复发。使用PubMed和GoogleScholar进行文献综述;关键术语为“血管内肌周细胞瘤”和“IVMP”。“在2002年1月至2022年1月发表的14篇文章中,发现了19例血管内肌皮细胞瘤。其中涉及11名男性和7名女性(1例性别不详);年龄为22至80岁(平均:59.8±14岁)。在大多数情况下,肿瘤生长缓慢,病因是既往手术史或外伤。面部或足部有肿瘤的患者没有报告疼痛,在任何报告的病例中,手术后均未观察到复发。平滑肌肌动蛋白的免疫组织化学染色,h-caldesmon,Calponin,CD34用于鉴别诊断。与文献中报道的缓慢生长性质相反,在本病例中,与生长有关的性质尚不清楚,由于血栓形成引起的突然疼痛而发现了病变。然而,我们病例的诊断方法和复发率与以前报道的病例相似.
结论:我们的病例表明,尽管血管内肌周细胞瘤很少见,它们会引起自发性血栓形成。完全切除后复发率低。在确定原因后,必须对罕见部位发生的自发性深静脉血栓形成进行治疗。
BACKGROUND: Intravascular myopericytomas are a rare type of myopericytomas. In most previously reported cases, these were benign, occurred on the legs or neck, and had low recurrence rates. We have described a unique
case of an intravascular myopericytoma that caused spontaneous deep vein thrombosis.
UNASSIGNED: A 37-year-old man presented with sudden-onset pain and swelling in the upper arm; physical examination revealed a 10 cm, palpable, firm, and mobile lesion in the upper arm. A biopsy revealed intravascular myopericytoma; immunohistological examination revealed a lesion in the lumen of the basilic vein. The tumor comprised abundant myxoid stroma with spindle cells proliferating in a concentric perivascular manner around the blood vessel. The tumor cells stained positive for CD34 and smooth muscle actin.
UNASSIGNED: The patient underwent total excision of the mass under local anesthesia; no recurrence was observed thereafter. A literature review was performed using PubMed and Google Scholar; the key terms were \"intravascular myopericytoma\" and \"IVMP.\" Nineteen cases of intravascular myopericytomas across 14 articles published between January 2002 and January 2022 were identified. These involved 11 men and 7 women (sex was unknown in 1
case); the ages were 22 to 80 years (mean: 59.8 ± 14 years). In most cases, the tumor was slow-growing, and the etiology was previous surgical history or trauma. No pain was reported by patients with tumors on the face or feet, and no recurrence was observed after surgery in any of the reported cases. Immunohistochemical staining for smooth muscle actin, h-caldesmon, calponin, and CD34 was performed for differential diagnosis. Contrary to the slow-growing nature reported in the literature, the nature related to growing in the present
case was unclear that lesion was discovered because of sudden pain caused by thrombosis. However, the diagnostic method and recurrence rate in our
case were similar to those in the previously reported cases.
CONCLUSIONS: Our
case shows that although intravascular myopericytomas are rare, they can cause spontaneous thrombosis. They have low recurrence rates after complete resection. Spontaneous deep vein thrombosis that occurs in rare locations must be treated after determining the causes.