目的:概述棘阿米巴角膜炎(AK)的发病率。
结论:虽然是人群中感染性角膜炎的主要原因,缺乏对这种情况发生率的全面评估。
方法:AK的发生率计算为AK眼的数量,每个医疗中心,每年(年化中心发病率,或ACI)。还计算了两个荟萃分析比率:a)AK眼与非病毒性微生物性角膜炎(MK)眼的比率;b)AK眼与总人口的比率(即一个国家或地区的学科总数,正如作者在每项研究中指出的那样)。中心被定义为医疗机构(例如,医院,私人执业,诊所)研究发生的地方。计算AK眼睛年的实际和预测估计值,乘以AK与总人口的比率以及相应的当前和预测人口估计值(年龄范围:15至70),来自联合国(UN)人口展望。
结果:总体而言,共包括105篇文章,1987年至2022年出版。确定的眼睛总数为91,951只,其中5,660只受到AK的影响,86,291只受到非病毒MK的影响。每个医疗中心每年的ACI中位数为1.9个新的AK眼(中位数为95CI:1.5至2.6),在各大洲之间没有观察到统计学上的显著差异。AK眼占MK眼总数的比例为1.52%(95CI:1.02%~2.24%),而AK与整个人口的比率估计为0.0002%(95CI:0.0001至0.0006),或每1,000,000名受试者2.34只眼(95CI:每1.000.000名受试者0.98至5.55)。与2023年的基线(12,954只AK眼)相比,预计AK眼的数量增加表明2053年的+18.5%(15,356只AK眼)和2073年的+25.5%(16,253只AK眼)。在不同大陆之间,其发病率没有显着差异。
OBJECTIVE: To provide an overview on the incidence of Acanthamoeba Keratitis (AK).
CONCLUSIONS: Although being a major and sight-threatening cause of infectious keratitis in the population, a comprehensive assessment of the incidence of this condition is lacking.
METHODS: Incidence of AK was computed as the number of AK eyes, per healthcare center, per year (annualized-center-incidence, or ACI). Two meta-analytical ratios were also calculated: a) the ratio of AK eyes to the count of non-viral microbial keratitis (MK) eyes; b) the ratio of AK eyes to the overall population (i.e., the total number of subjects of a nation or region, as indicated by the authors in each study). Center was defined as the healthcare facility (e.g., Hospital, Private Practice, Clinic) where the study took place. Actual and projected estimates of the number of AK eyes in years were calculated multiplying the ratio of AK to the total population and the corresponding present and projected population estimates (age range: 15 to 70), sourced from the United Nations (UN) Population Prospects.
RESULTS: Overall, 105 articles were included, published between 1987 and 2022. The total number of eyes identified was 91,951, with 5,660 affected by AK and 86,291 by non-viral MK. The median ACI was 1.9 new AK eyes per healthcare center per year (95%CI of the median: 1.5 to 2.6), with no statistically significant differences observed among continents. The ratio of AK eyes to the total number of MK eyes was 1.52% (95%CI: 1.02% to 2.24%), while the ratio of AK in relation to the entire population was estimated at 0.0002% (95%CI: 0.0001 to 0.0006), or 2.34 eyes per 1,000,000 subjects (95%CI: 0.98 to 5.55 per 1.000.000 subjects). The projected increase in the numbers of AK eyes indicates a rise of +18.5% (15,356 AK eyes) in 2053 and +25.5% (16,253 AK eyes) in 2073, compared to the baseline of 2023 (12,954 AK eyes) CONCLUSION: AK emerged as a relatively low-incident disorder, and no significant differences in terms of its incidence were found among different continents.