职业风险引起的白血病是一个需要更多关注和亟待解决的问题,特别是急性淋巴细胞白血病(ALL),急性髓系白血病(AML),慢性淋巴细胞白血病(CLL)。然而,关于这个问题的文献很少。我们旨在评估1990年至2019年归因于职业风险的白血病的全球负担和趋势。
这项观察趋势研究基于2019年全球疾病负担(GBD)数据库。全球死亡,和残疾调整寿命年(DALYs),它们被计算以量化归因于职业风险的白血病的变化趋势,按年龄分析,Year,地理位置,和社会人口指数(SDI),并计算了相应的估计年度百分比变化(EAPC)值。
全球年龄标准化DALYs和由职业风险引起的白血病死亡率呈现显著下降趋势,EAPC[DALYs为-0.38%(95%CI:-0.58至-0.18%),死亡为-0.30%(95%CI:-0.45至-0.146%)]。然而,在65-69岁的人群中,这一比例显著升高[DALYs为0.42%(95%CI:0.30-0.55%),死亡为0.38%(95%CI:0.26-0.51%)].同时,所有人的年龄标准化DALYS和死亡率,AML,和CLL在EAPC中呈现显着增加的趋势[0.78%(95%CI:0.65-0.91%),0.87%(95%CI:0.81-0.93%),和0.66%(95%CI:0.51-0.81%)的DALYs,分别,和0.75%(95%CI:0.68-0.82%),0.96%(95%CI:0.91-1.01%),死亡为0.55%(95%CI:0.43-0.68%)],分别。所有,AML,CLL在几乎所有年龄组均呈上升趋势。
我们观察到,在1990年至2019年期间,由于职业风险,白血病的人数大幅减少。然而,65-69岁的人和所有人的负担,AML,CLL在几乎所有年龄组都有显著增加的趋势.因此,目前仍迫切需要加快努力,以减少该人群中与职业风险相关的死亡负担和特定原因引起的白血病.
Leukemia caused by occupational risk is a problem that needs more attention and remains to be solved urgently, especially for acute lymphoid leukemia (
ALL), acute myeloid leukemia (AML), and chronic lymphoid leukemia (CLL). However, there is a paucity of literature on this issue. We aimed to assess the global burden and trends of leukemia attributable to occupational risk from 1990 to 2019.
This observational trend
study was based on the Global Burden of Disease (GBD) 2019 database, the global deaths, and disability-adjusted life years (DALYs), which were calculated to quantify the changing trend of leukemia attributable to occupational risk, were analyzed by age, year, geographical location, and socio-demographic index (SDI), and the corresponding estimated annual percentage change (EAPC) values were calculated.
Global age-standardized DALYs and death rates of leukemia attributable to occupational risk presented significantly decline trends with EAPC [-0.38% (95% CI: -0.58 to -0.18%) for DALYs and -0.30% (95% CI: -0.45 to -0.146%) for death]. However, it was significantly increased in people aged 65-69 years [0.42% (95% CI: 0.30-0.55%) for DALYs and 0.38% (95% CI: 0.26-0.51%) for death]. At the same time, the age-standardized DALYs and death rates of ALL, AML, and CLL were presented a significantly increased trend with EAPCs [0.78% (95% CI: 0.65-0.91%), 0.87% (95% CI: 0.81-0.93%), and 0.66% (95% CI: 0.51-0.81%) for DALYs, respectively, and 0.75% (95% CI: 0.68-0.82%), 0.96% (95% CI: 0.91-1.01%), and 0.55% (95% CI: 0.43-0.68%) for death], respectively. The
ALL, AML, and CLL were shown an upward trend in almost
all age groups.
We observed a substantial reduction in leukemia due to occupational risks between 1990 and 2019. However, the people aged 65-69 years and burdens of
ALL, AML, and CLL had a significantly increased trend in almost
all age groups. Thus, there remains an urgent need to accelerate efforts to reduce leukemia attributable to occupational risk-related death burden in this population and specific causes.