腺苷酸环化酶3(ADCY3)基因参与多种代谢过程的调节,包括脂肪组织的发育和功能。在饮食干预16周后,测试了ADCY3rs10182181遗传变异对身体组成变化的影响,这取决于大量营养素的摄入量。在147名超重或肥胖受试者中对ADCY3遗传变异进行了基因分型,他们被随机分配到两种不同营养素含量的饮食中的一种:中高蛋白饮食和低脂肪饮食。记录人体测量和身体成分测量(DEXA扫描)。ADCY3基因型和饮食干预对体重变化的显着相互作用,腰围,和体成分是在调整协变量后发现的。因此,在中等高蛋白饮食组中,G等位基因与较低的脂肪量减少有关,树干和机器人脂肪,瘦肉质量下降幅度更大。相反,在携带G等位基因的低脂饮食组中,躯干的减少幅度更大,android,gynoid,还有内脏脂肪.与中高蛋白饮食相比,携带rs10182181多态性G等位基因的受试者在进行低热量低脂肪饮食时,在体重减轻和改善身体成分测量方面可能会受益更多。
The adenylate cyclase 3 (
ADCY3) gene is involved in the regulation of several metabolic processes including the development and function of adipose tissue. The effects of the
ADCY3 rs10182181 genetic variant on changes in body composition depending on the macronutrient distribution intake after 16 weeks of the dietary intervention were tested. The
ADCY3 genetic variant was genotyped in 147 overweight or obese subjects, who were randomly assigned to one of the two diets varying in macronutrient content: a moderately-high-protein diet and a low-fat diet. Anthropometric and body composition measurements (DEXA scan) were recorded. Significant interactions between the
ADCY3 genotype and dietary intervention on changes in weight, waist circumference, and body composition were found after adjustment for covariates. Thus, in the moderately-high-protein diet group, the G allele was associated with a lower decrease of fat mass, trunk and android fat, and a greater decrease in lean mass. Conversely, in the low-fat diet group carrying the G allele was associated with a greater decrease in trunk, android, gynoid, and visceral fat. Subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet.