Although acute coronary syndromes remain crucial diagnoses of chest pain that cannot be missed, there are several other potentially fatal diagnoses that can manifest similarly. This case report applies the 2021 chest pain guidelines emphasizing the importance of considering alternative nonischemic but still serious presentations under the umbrella of chest pain. (Level of Difficulty: Advanced.).

We applied the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR chest pain guidelines to a case of a 76-year-old woman with no known coronary disease presenting to the emergency department with acute chest pain and an intermediate probability of acute coronary syndrome. Her workup per the guidelines involved rapid electrocardiogram, high-sensitivity troponins, nuclear stress testing, and eventually coronary invasive angiography. (Level of Difficulty: Advanced.).