Determinant of cistron specificity in bacterial ribosomes.

细菌核糖体顺反子特异性的决定因素。

• 影响指数: 69.504
• 发表时间: Mar 1975 6
• 来源期刊: Nature
• DOI: 10.1038/254034a0
• PMID: 803646
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 综合性期刊
• 作者列表: Shine J,Dalgarno L

Mesh: Bacillus; Base Sequence; Binding Sites; Coliphages; Escherichia coli; Genes; Genetic Code; Peptide Initiation Factors; Protein Biosynthesis; Pseudomonas aeruginosa; RNA, Bacterial / metabolism; RNA, Ribosomal / metabolism; Ribosomes / metabolism; Species Specificity

Abstract

The sequence of the 3\'-terminus of 16S RNA from different bacteria has been determined. Complementarity relationships between this sequence and a purine-rich tract in the ribosome binding site of different bacterial mRNAs suggest that the 3\'-end of 16S RNA determines the intrinsic capacity of ribosomes to translate a particular cistron.

摘要

已经确定了来自不同细菌的16SRNA的3'末端的序列。该序列与不同细菌mRNA的核糖体结合位点中富含嘌呤的片段之间的互补关系表明，16SRNA的3'端决定了核糖体翻译特定顺反子的内在能力。