PDF(Pubmed)
Abstract：
Gastrointestinal function plays a pivotal role in nutrient absorption and overall digestive health. Abnormal gastric emptying is closely linked to type 2 diabetes, impacting blood glucose regulation and causing gastrointestinal symptoms. This study aims to investigate and compare segmental transit times, motility indices, and micromilieu between Greenlandic Inuit and Danish individuals with and without type 2 diabetes. We included forty-four Greenlandic Inuit, twenty-three of whom had type 2 diabetes, and age and gender-matched Danish individuals. Segmental transit time, motility, and luminal environment were measured using the SmartPill®. Greenlandic controls displayed shorter gastric emptying time (GET) (163 min), higher gastric median pH (2.0 pH) and duodenal median contractions (18.2 mm Hg) compared to Greenlanders with type 2 diabetes (GET: 235 min, pH:1.9, median duodenal contraction 18.4 mm Hg) and Danish controls (GET: 190, pH:1.2 median duodenal contraction 17.5 mmHg). Despite similar anti-diabetic management efforts, variations in gastrointestinal physiology were evident, highlighting the complexity of diabetes and its interaction with ethnicity, suggesting potential dietary or even genetic influences, emphasising the necessity for personalised diabetes management approaches. Finally, the study opens possibilities for future research, encouraging investigations into the underlying mechanisms linking genetics, diet, and gastric physiology, as an understanding of factors can lead to more effective, tailored strategies for diabetes care and improved digestive health in diverse populations.
摘要：
胃肠道功能在营养吸收和整体消化健康中起着关键作用。胃排空异常与2型糖尿病密切相关。影响血糖调节并引起胃肠道症状。本研究旨在调查和比较分段运输时间，运动性指数，格陵兰因纽特人和有或没有2型糖尿病的丹麦个体之间的微环境。我们包括了44名格陵兰因纽特人，其中23人患有2型糖尿病，以及年龄和性别匹配的丹麦人。分段运输时间，运动性,和腔环境使用SmartPill®测量。格陵兰对照显示较短的胃排空时间（GET）（163分钟），与2型糖尿病的格陵兰人相比，胃的中位pH（2.0pH）和十二指肠中位收缩（18.2mmHg）更高（GET：235分钟，pH：1.9，中位十二指肠收缩18.4mmHg）和丹麦对照（GET：190，pH：1.2中位十二指肠收缩17.5mmHg）。尽管有类似的抗糖尿病管理努力，胃肠道生理学的变化是明显的，强调糖尿病的复杂性及其与种族的相互作用，暗示潜在的饮食甚至遗传影响，强调个性化糖尿病管理方法的必要性。最后,这项研究为未来的研究开辟了可能性，鼓励研究与遗传学相关的潜在机制，饮食，和胃生理学，因为对因素的理解可以导致更有效的，为不同人群的糖尿病护理和改善消化系统健康量身定制的策略。
