PDF(Pubmed)
Abstract：
UNASSIGNED: The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures.
UNASSIGNED: To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years.
UNASSIGNED: The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022.
UNASSIGNED: Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse.
UNASSIGNED: Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models.
UNASSIGNED: A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = -0.29; SE = 0.03; P < .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P < .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P < .001) and the personality domain (β = 0.07; SE = 0.02; P < .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = -0.04; SE = 0.02; P = .045) and its development over time (β = -0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model.
UNASSIGNED: The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.
UNASSIGNED: To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years.
UNASSIGNED: The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022.
UNASSIGNED: Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse.
UNASSIGNED: Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models.
UNASSIGNED: A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = -0.29; SE = 0.03; P < .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P < .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P < .001) and the personality domain (β = 0.07; SE = 0.02; P < .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = -0.04; SE = 0.02; P = .045) and its development over time (β = -0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model.
UNASSIGNED: The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.
摘要：
■青少年饮酒障碍的发展与未来酒精依赖的风险增加有关。在8年的过程中，危险因素与饮酒的不同关联对于预防措施很重要。
■为了确定性格的冒险方面的差异关联，社会因素,大脑功能,以及在8年的过程中，青少年使用有害酒精的家族风险。
■IMAGEN多中心纵向队列研究包括从德国欧洲学校招募的青少年，英国,法国,和爱尔兰从2008年1月到2019年1月。符合条件的参与者包括那些有神经心理学，自我报告,成像,和基线时的遗传数据。不符合磁共振成像条件或患有严重疾病的青少年被排除在外。数据分析于2021年7月至2022年9月进行。
■个性测试，社会心理因素,大脑功能,和家族性酒精滥用风险。
■使用酒精使用障碍鉴定测试分数衡量的有害酒精使用情况，IMAGEN研究的主要计划结果。使用潜在生长曲线模型对14、16、19和22岁的酒精滥用轨迹进行建模。
■总共2240名青少年（1110名女性[49.6%]和1130名男性[50.4%]）被纳入研究。心理社会资源（β=-0.29;SE=0.03;P<.001）与酒精滥用的一般风险之间存在显着负相关，而人格的风险承担方面与截距之间存在显着正相关（β=0.19;SE=0.04;P<.001）。此外，社会领域(β=0.13;SE=0.02;P<.001)和人格领域(β=0.07;SE=0.02;P<.001)与酒精滥用随时间(斜率)发展的轨迹存在显著正相关。药物滥用家族史与酒精滥用的一般风险（β=-0.04;SE=0.02;P=0.045）及其随时间的发展（β=-0.03;SE=0.01;P=0.01）呈负相关。在模型中，脑功能与酒精滥用的截距或斜率没有显着关联。
■这项队列研究的结果表明，青少年饮酒的已知危险因素可能会导致未来的酒精滥用。这种方法可以提供更个性化的预防性干预措施。
■为了确定性格的冒险方面的差异关联，社会因素,大脑功能,以及在8年的过程中，青少年使用有害酒精的家族风险。
■IMAGEN多中心纵向队列研究包括从德国欧洲学校招募的青少年，英国,法国,和爱尔兰从2008年1月到2019年1月。符合条件的参与者包括那些有神经心理学，自我报告,成像,和基线时的遗传数据。不符合磁共振成像条件或患有严重疾病的青少年被排除在外。数据分析于2021年7月至2022年9月进行。
■个性测试，社会心理因素,大脑功能,和家族性酒精滥用风险。
■使用酒精使用障碍鉴定测试分数衡量的有害酒精使用情况，IMAGEN研究的主要计划结果。使用潜在生长曲线模型对14、16、19和22岁的酒精滥用轨迹进行建模。
■总共2240名青少年（1110名女性[49.6%]和1130名男性[50.4%]）被纳入研究。心理社会资源（β=-0.29;SE=0.03;P<.001）与酒精滥用的一般风险之间存在显着负相关，而人格的风险承担方面与截距之间存在显着正相关（β=0.19;SE=0.04;P<.001）。此外，社会领域(β=0.13;SE=0.02;P<.001)和人格领域(β=0.07;SE=0.02;P<.001)与酒精滥用随时间(斜率)发展的轨迹存在显著正相关。药物滥用家族史与酒精滥用的一般风险（β=-0.04;SE=0.02;P=0.045）及其随时间的发展（β=-0.03;SE=0.01;P=0.01）呈负相关。在模型中，脑功能与酒精滥用的截距或斜率没有显着关联。
■这项队列研究的结果表明，青少年饮酒的已知危险因素可能会导致未来的酒精滥用。这种方法可以提供更个性化的预防性干预措施。
