PDF(Pubmed)
Abstract：
Periodontitis is an inflammatory disease caused by bacterial biofilms, which leads to the destruction of periodontal tissue. Current treatments, such as mechanical cleaning and antibiotics, struggle to effectively address the persistent biofilms, inflammation, and tissue damage. A new approach involves developing a Janus nanomotor (J-CeM@Au) by coating cerium dioxide-doped mesoporous silica (CeM) with gold nanoparticles (AuNPs). This nanomotor exhibits thermophoretic motion when exposed to near-infrared (NIR) laser light due to the temperature gradient produced by the photothermal effects of asymmetrically distributed AuNPs. The NIR laser provides the energy for propulsion and activates the nanomotor\'s antibacterial properties, allowing it to penetrate biofilms and kill bacteria. Additionally, the nanomotor\'s ability to scavenge reactive oxygen species (ROS) can modulate the immune response and create a regenerative environment, promoting the healing of periodontal tissue. Overall, this multifunctional nanomotor offers a promising new approach for treating periodontitis by simultaneously addressing biofilm management and immune modulation with autonomous movement.
摘要：
牙周炎是由细菌生物膜引起的炎症性疾病，导致牙周组织的破坏。目前的治疗方法,比如机械清洗和抗生素，努力有效地解决持久性生物膜，炎症,和组织损伤。一种新方法涉及通过用金纳米颗粒（AuNP）涂覆二氧化铈掺杂的介孔二氧化硅（CeM）来开发Janus纳米马达（J-CeM@Au）。由于不对称分布的AuNP的光热效应产生的温度梯度，当暴露于近红外（NIR）激光时，该纳米马达表现出热泳运动。近红外激光为推进提供能量并激活纳米马达的抗菌性能，让它穿透生物膜杀死细菌.此外,纳米马达清除活性氧（ROS）的能力可以调节免疫反应并创造再生环境，促进牙周组织的愈合。总的来说,这种多功能纳米马达为牙周炎的治疗提供了一种有前景的新方法，它通过自主运动同时解决生物膜管理和免疫调节。
