PDF(Pubmed)
Abstract：
This review explores the intricate connections between type 2 diabetes (T2D) and Parkinson\'s disease (PD), both prevalent chronic conditions that primarily affect the aging population. These diseases share common early biochemical pathways that contribute to tissue damage. This manuscript also systematically compiles potential shared cellular mechanisms between T2D and PD and discusses the literature on the utilization of antidiabetic drugs as potential therapeutic options for PD. This review encompasses studies investigating the experimental and clinical efficacy of antidiabetic drugs in the treatment of Parkinson\'s disease, along with the proposed mechanisms of action. The exploration of the benefits of antidiabetic drugs in PD presents a promising avenue for the treatment of this neurodegenerative disorder.
摘要：
这篇综述探讨了2型糖尿病(T2D)和帕金森病(PD)之间的复杂联系。两种主要影响人口老龄化的普遍慢性疾病。这些疾病具有共同的早期生化途径，可导致组织损伤。该手稿还系统地汇编了T2D和PD之间潜在的共享细胞机制，并讨论了有关使用抗糖尿病药物作为PD潜在治疗选择的文献。这篇综述包括研究抗糖尿病药物治疗帕金森病的实验和临床疗效的研究。以及拟议的行动机制。对PD中抗糖尿病药物益处的探索为治疗这种神经退行性疾病提供了有希望的途径。
