PDF(Pubmed)
Abstract：
UNASSIGNED: Chronic kidney disease(CKD) is a global medical problem. Serum methylmalonic acid(MMA) is a serum marker associated with many diseases. This study aimed to investigate the association between MMA and CKD.
UNASSIGNED: Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were downloaded and analyzed. The association between MMA and CKD was confirmed by using multiple logistic regression modeling. The smooth curve fitting method was used to investigate the nonlinear relationship between them. Subgroup analyses and interaction tests were used to verify the stability of the association between different subgroups. Threshold effect analysis was used to determine the optimal control point for MMA.
UNASSIGNED: There was a unique W-shaped nonlinear relationship between MMA and the risk of CKD, with a positive correlation between them (OR=1.66,95% CI:1.27, 2.17; P=0.0002). As the stage of CKD progressed, MMA levels increased. Age, hypertension, and serum vitamin B12 had significant influences on the association between MMA and the risk of CKD.
UNASSIGNED: Our findings revealed that serum MMA accumulation was positively associated with the risk of CKD. Serum MMA level may be a novel index to predict the development and course of CKD. This study may help in the early identification of people at risk for chronic kidney disease and provide new ideas and approaches for prevention and treatment.
UNASSIGNED: Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were downloaded and analyzed. The association between MMA and CKD was confirmed by using multiple logistic regression modeling. The smooth curve fitting method was used to investigate the nonlinear relationship between them. Subgroup analyses and interaction tests were used to verify the stability of the association between different subgroups. Threshold effect analysis was used to determine the optimal control point for MMA.
UNASSIGNED: There was a unique W-shaped nonlinear relationship between MMA and the risk of CKD, with a positive correlation between them (OR=1.66,95% CI:1.27, 2.17; P=0.0002). As the stage of CKD progressed, MMA levels increased. Age, hypertension, and serum vitamin B12 had significant influences on the association between MMA and the risk of CKD.
UNASSIGNED: Our findings revealed that serum MMA accumulation was positively associated with the risk of CKD. Serum MMA level may be a novel index to predict the development and course of CKD. This study may help in the early identification of people at risk for chronic kidney disease and provide new ideas and approaches for prevention and treatment.
摘要：
■慢性肾脏疾病（CKD）是一个全球性的医学问题。血清甲基丙二酸（MMA）是与许多疾病有关的血清标志物。本研究旨在探讨MMA与CKD的相关性。
■下载并分析了2013-2014年国家健康和营养检查调查（NHANES）的数据。MMA和CKD之间的关联通过使用多元逻辑回归模型得到证实。采用光滑曲线拟合方法研究了它们之间的非线性关系。亚组分析和交互作用检验用于验证不同亚组之间关联的稳定性。阈值效应分析用于确定MMA的最佳控制点。
■MMA与CKD风险之间存在独特的W形非线性关系，两者呈正相关(OR=1.66,95%CI:1.27,2.17;P=0.0002)。随着CKD阶段的进展，MMA水平升高。年龄,高血压,血清维生素B12对MMA与CKD风险的相关性有显著影响。
■我们的研究结果表明，血清MMA积累与CKD的风险正相关。血清MMA水平可能是预测CKD发展和病程的新指标。本研究有助于早期识别慢性肾脏病高危人群,为慢性肾脏病的防治提供新的思路和途径。
■下载并分析了2013-2014年国家健康和营养检查调查（NHANES）的数据。MMA和CKD之间的关联通过使用多元逻辑回归模型得到证实。采用光滑曲线拟合方法研究了它们之间的非线性关系。亚组分析和交互作用检验用于验证不同亚组之间关联的稳定性。阈值效应分析用于确定MMA的最佳控制点。
■MMA与CKD风险之间存在独特的W形非线性关系，两者呈正相关(OR=1.66,95%CI:1.27,2.17;P=0.0002)。随着CKD阶段的进展，MMA水平升高。年龄,高血压,血清维生素B12对MMA与CKD风险的相关性有显著影响。
■我们的研究结果表明，血清MMA积累与CKD的风险正相关。血清MMA水平可能是预测CKD发展和病程的新指标。本研究有助于早期识别慢性肾脏病高危人群,为慢性肾脏病的防治提供新的思路和途径。
