Abstract：
Bionic electrical stimulation (Bio-ES) aims to achieve personalized therapy and proprioceptive adaptation by mimicking natural neural signatures of the body, while current Bio-ES devices are reliant on complex sensing and computational simulation systems, thus often limited by the low-fidelity of simulated electrical signals, and failure of interface information interaction due to the mechanical mismatch between soft tissues and rigid electrodes. Here, the study presents a flexible and ultrathin self-sustainable bioelectronic patch (Bio-patch), which can self-adhere to the lesion area of organs and generate bionic electrical signals synchronized vagal nerve envelope in situ to implement Bio-ES. It allows adaptive adjustment of intensity, frequency, and waveform of the Bio-ES to fully meet personalized needs of tissue regeneration based on real-time feedback from the vagal neural controlled organs. With this foundation, the Bio-patch can effectively intervene with excessive fibrosis and microvascular stasis during the natural healing process by regulating the polarization time of macrophages, promoting the reconstruction of the tissue-engineered structure, and accelerating the repair of damaged liver and kidney. This work develops a practical approach to realize biomimetic electronic modulation of the growth and development of soft organs only using a multifunctional Bio-patch, which establishes a new paradigm for precise bioelectronic medicine.
摘要：
仿生电刺激（Bio-ES）旨在通过模仿身体的自然神经特征来实现个性化治疗和本体感受适应，虽然当前的Bio-ES设备依赖于复杂的传感和计算模拟系统，因此通常受到模拟电信号的低保真度的限制，以及由于软组织和刚性电极之间的机械不匹配而导致的界面信息交互失败。这里,该研究提出了一种灵活且超薄的可自我维持的生物电子贴片（Bio-patch），能自我粘附于器官的病变区域,并在原位产生同步迷走神经包膜的仿生电信号,从而实现Bio-ES。它允许强度的自适应调整，频率,基于迷走神经控制器官的实时反馈，充分满足个性化的组织再生需求。有了这个基础,Bio-patch通过调节巨噬细胞的极化时间,有效干预自然愈合过程中的过度纤维化和微血管淤滞,促进组织工程结构的重建，加速受损肝脏和肾脏的修复.这项工作开发了一种实用的方法，仅使用多功能生物贴片即可实现对软器官生长发育的仿生电子调制，这为精确的生物电子医学建立了新的范式。
