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Abstract：
BACKGROUND: Myxofibrosarcoma is a myxoid soft tissue sarcoma showing T2 high intensity on magnetic resonance imaging. However, myxofibrosarcoma is a heterogeneous sarcoma with both myxoid and cellular portions. Magnetic resonance imaging findings were obtained MRI findings for comparison with histological and Ki-67 immunohistochemical features, in different portions of one myxofibrosarcoma.
METHODS: Magnetic resonance imaging observations were compared with gross pathological and microscopic findings of a myxofibrosarcoma from a 50-year-old Japanese female. The Ki-67 labeling indices of different portions of the tumor, that is, the myxoid, cellular, and histologically confirmed infiltrative margin portions (pathological tail sign), were compared. The T2 low intensity area was more cellular than the T2 high intensity area, while the cellular portion had a significantly higher Ki-67 index than the myxoid portion (p = 0.0313). The portions with the pathological tail sign had a significantly higher Ki-67 labeling index than those without this sign (p = 0.0313).
CONCLUSIONS: More cellular portions of a myxofibrosarcoma correspond to more areas of the tumor showing aggressive features. Furthermore, our data also support the hypothesis of high aggressiveness being associated with the pathological tail sign in myxofibrosarcoma. To our knowledge, this is the first case report to describe comparisons among the imaging findings, histological features, and Ki-67 immunohistochemistry results for different portions of one myxofibrosarcoma.
METHODS: Magnetic resonance imaging observations were compared with gross pathological and microscopic findings of a myxofibrosarcoma from a 50-year-old Japanese female. The Ki-67 labeling indices of different portions of the tumor, that is, the myxoid, cellular, and histologically confirmed infiltrative margin portions (pathological tail sign), were compared. The T2 low intensity area was more cellular than the T2 high intensity area, while the cellular portion had a significantly higher Ki-67 index than the myxoid portion (p = 0.0313). The portions with the pathological tail sign had a significantly higher Ki-67 labeling index than those without this sign (p = 0.0313).
CONCLUSIONS: More cellular portions of a myxofibrosarcoma correspond to more areas of the tumor showing aggressive features. Furthermore, our data also support the hypothesis of high aggressiveness being associated with the pathological tail sign in myxofibrosarcoma. To our knowledge, this is the first case report to describe comparisons among the imaging findings, histological features, and Ki-67 immunohistochemistry results for different portions of one myxofibrosarcoma.
摘要：
背景：粘液纤维肉瘤是一种在磁共振成像上显示T2强度高的粘液样软组织肉瘤。然而,粘液纤维肉瘤是具有粘液样和细胞部分的异质肉瘤。磁共振成像结果获得的MRI结果与组织学和Ki-67免疫组织化学特征进行比较，在一个黏液纤维肉瘤的不同部位.
方法：将磁共振成像观察结果与一名50岁日本女性粘液纤维肉瘤的大体病理和显微镜发现进行比较。肿瘤不同部位的Ki-67标记指数,也就是说,粘液样，细胞，和组织学证实的浸润边缘部分（病理性尾征），进行了比较。T2低强度区域比T2高强度区域细胞更多，而细胞部分的Ki-67指数明显高于黏液部分（p=0.0313）。具有病理性尾部体征的部分的Ki-67标记指数明显高于没有该体征的部分（p=0.0313）。
结论：粘液纤维肉瘤的更多细胞部分对应于显示侵袭性特征的更多肿瘤区域。此外，我们的数据也支持高侵袭性与黏液纤维肉瘤的病理性尾征相关的假设.据我们所知,这是第一份描述影像学发现之间比较的病例报告，组织学特征，1例黏液纤维肉瘤不同部位的Ki-67免疫组织化学结果。
方法：将磁共振成像观察结果与一名50岁日本女性粘液纤维肉瘤的大体病理和显微镜发现进行比较。肿瘤不同部位的Ki-67标记指数,也就是说,粘液样，细胞，和组织学证实的浸润边缘部分（病理性尾征），进行了比较。T2低强度区域比T2高强度区域细胞更多，而细胞部分的Ki-67指数明显高于黏液部分（p=0.0313）。具有病理性尾部体征的部分的Ki-67标记指数明显高于没有该体征的部分（p=0.0313）。
结论：粘液纤维肉瘤的更多细胞部分对应于显示侵袭性特征的更多肿瘤区域。此外，我们的数据也支持高侵袭性与黏液纤维肉瘤的病理性尾征相关的假设.据我们所知,这是第一份描述影像学发现之间比较的病例报告，组织学特征，1例黏液纤维肉瘤不同部位的Ki-67免疫组织化学结果。
