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Abstract：
BACKGROUND: Tuberculosis (TB) is a leading cause of death among children living with HIV (CLHIV). Isoniazid preventive therapy (IPT) reduces the incidence of TB by 70% and mortality by 50% among CLHIV. However, in most developing countries including Tanzania, the uptake of IPT is suboptimal, below the 90% WHO-global uptake target. We assessed the factors associated with IPT uptake among CLHIV in Mwanza region, Tanzania.
METHODS: This was a multicenter facility-based cross-sectional study among CLHIV aged 1 to 10 years in seven districts of Mwanza region, Tanzania from 1st November 2021 to 20th January 2022. Data were collected using a structured interview-administered questionnaire including information on children and caregivers\' demographics, caregivers\' health related information and children\'s clinical information. Our outcome variable was uptake of IPT, defined as initiation on IPT either during the time of the study or within past three years before this study We conducted modified Poisson regression to assess the association between IPT uptake and selected exposures in Stata version 15.0.
RESULTS: A total of 415 CLHIV were enrolled, the median age of the children was 7 years (Interquartile range: 5-8). The uptake of IPT was 91% (n = 377). The majority of children\'s caregivers were HIV positive (86%, n = 387) and were aware about IPT (63.6%, n = 264). Factors associated with IPT uptake included; having an employed caregiver [Adjusted Prevalence Ratio (aPR): 1.06 95% Confidence Interval (CI): 1.00-1.13] and attending the ART clinic every month [aPR: 1.00; 95% CI: 0.87-1.00] .
CONCLUSIONS: The uptake of IPT uptake among CLHIV in Mwanza, Tanzania exceeds the global WHO-target of ≥ 90%. Monthly ART clinic visits could be essential in promoting IPT uptake among CLHIV.
METHODS: This was a multicenter facility-based cross-sectional study among CLHIV aged 1 to 10 years in seven districts of Mwanza region, Tanzania from 1st November 2021 to 20th January 2022. Data were collected using a structured interview-administered questionnaire including information on children and caregivers\' demographics, caregivers\' health related information and children\'s clinical information. Our outcome variable was uptake of IPT, defined as initiation on IPT either during the time of the study or within past three years before this study We conducted modified Poisson regression to assess the association between IPT uptake and selected exposures in Stata version 15.0.
RESULTS: A total of 415 CLHIV were enrolled, the median age of the children was 7 years (Interquartile range: 5-8). The uptake of IPT was 91% (n = 377). The majority of children\'s caregivers were HIV positive (86%, n = 387) and were aware about IPT (63.6%, n = 264). Factors associated with IPT uptake included; having an employed caregiver [Adjusted Prevalence Ratio (aPR): 1.06 95% Confidence Interval (CI): 1.00-1.13] and attending the ART clinic every month [aPR: 1.00; 95% CI: 0.87-1.00] .
CONCLUSIONS: The uptake of IPT uptake among CLHIV in Mwanza, Tanzania exceeds the global WHO-target of ≥ 90%. Monthly ART clinic visits could be essential in promoting IPT uptake among CLHIV.
摘要：
背景：结核病（TB）是感染艾滋病毒（CLHIV）的儿童死亡的主要原因。异烟肼预防性治疗（IPT）可将CLHIV中TB的发病率降低70％，死亡率降低50％。然而,在包括坦桑尼亚在内的大多数发展中国家，IPT的摄取次优，低于世卫组织全球吸收目标的90%。我们评估了姆万扎地区CLHIV中与IPT摄取相关的因素，坦桑尼亚。
方法：这是一项基于多中心设施的横断面研究，对姆万扎地区7个地区1至10岁的CLHIV进行了研究，坦桑尼亚从2021年11月1日至2022年1月20日。数据是使用结构化访谈管理的问卷收集的，包括儿童和照顾者的人口统计信息，护理人员健康相关信息和儿童临床信息。我们的结果变量是IPT的摄取，定义为在研究期间或研究前的过去三年内开始接受IPT。我们进行了改良的Poisson回归，以评估Stata版本15.0中IPT摄取与选定暴露之间的关联。
结果：共纳入415个CLHIV，儿童的中位年龄为7岁(四分位距:5-8岁).IPT的摄取为91%(n=377)。大多数儿童的照顾者是艾滋病毒阳性(86%，n=387)，并且了解IPT(63.6%，n=264）。与IPT摄取相关的因素包括：雇用护理人员[调整后的患病率比（aPR）：1.0695％置信区间（CI）：1.00-1.13]和每月到ART诊所就诊[aPR：1.00;95％CI：0.87-1.00]。
结论：姆万扎CLHIV中IPT摄取的摄取，坦桑尼亚超过了世卫组织90%以上的全球目标。每月ART诊所访问对于促进CLHIV中IPT的吸收至关重要。
方法：这是一项基于多中心设施的横断面研究，对姆万扎地区7个地区1至10岁的CLHIV进行了研究，坦桑尼亚从2021年11月1日至2022年1月20日。数据是使用结构化访谈管理的问卷收集的，包括儿童和照顾者的人口统计信息，护理人员健康相关信息和儿童临床信息。我们的结果变量是IPT的摄取，定义为在研究期间或研究前的过去三年内开始接受IPT。我们进行了改良的Poisson回归，以评估Stata版本15.0中IPT摄取与选定暴露之间的关联。
结果：共纳入415个CLHIV，儿童的中位年龄为7岁(四分位距:5-8岁).IPT的摄取为91%(n=377)。大多数儿童的照顾者是艾滋病毒阳性(86%，n=387)，并且了解IPT(63.6%，n=264）。与IPT摄取相关的因素包括：雇用护理人员[调整后的患病率比（aPR）：1.0695％置信区间（CI）：1.00-1.13]和每月到ART诊所就诊[aPR：1.00;95％CI：0.87-1.00]。
结论：姆万扎CLHIV中IPT摄取的摄取，坦桑尼亚超过了世卫组织90%以上的全球目标。每月ART诊所访问对于促进CLHIV中IPT的吸收至关重要。
