PDF(Pubmed)
Abstract：
Bilharzia is a parasitic flatworm that causes schistosomiasis, a neglected tropical illness worldwide. Praziquantel (PZQ) is a commercial single treatment of schistosomiasis so alternative drugs are needed to get rid of its side effects on the liver. The current study aimed to estimate the effective role of Ficus carica nanoparticles (Fc-NPCs), silver nanoparticles (Ag-NPCs) and Ficus carica nanoparticles loaded on silver nanoparticles (Fc-Ag NPCs) on C57BL/6 black female mice infected by Schistosoma mansoni and treated with PZQ treatment. It was proved that schistosomiasis causes liver damage in addition to the PZQ is ineffective as an anti-schistosomiasis; it is recorded in the infected mice group and PZQ treated group as in liver function tests, oxidative stress markers & anti-oxidants, pro-inflammatory markers, pro-apoptotic and anti-apoptotic markers also in liver cells\' DNA damage. The amelioration in all tested parameters has been clarified in nanoparticle-protected mice groups. The Fc-Ag NPCs + PZQ group recorded the best preemptive effects as anti-schistosomiasis. Fc-NPCs, Ag-NPCs and Fc-Ag NPCs could antagonize PZQ effects that were observed in amelioration of all tested parameters. The study showed the phytochemicals\' nanoparticles groups have an ameliorated effect on the health of infected mice.
摘要：
Bilharzia是一种引起血吸虫病的寄生扁虫，一种全球被忽视的热带病。吡喹酮（PZQ）是血吸虫病的商业单一治疗方法，因此需要替代药物来消除其对肝脏的副作用。目前的研究旨在评估无花果纳米颗粒（Fc-NPC）的有效作用，在感染曼氏血吸虫并用PZQ处理的C57BL/6黑色雌性小鼠上，负载银纳米颗粒（Fc-AgNPC）和无花果纳米颗粒。事实证明，除了PZQ作为抗血吸虫病无效外，血吸虫病还会引起肝损伤；在肝功能测试中，在感染小鼠组和PZQ治疗组中都有记录，氧化应激标志物和抗氧化剂，促炎标志物，肝细胞DNA损伤中也有促凋亡和抗凋亡标志物。所有测试参数的改善已经在纳米颗粒保护的小鼠组中得到澄清。Fc-AgNPCs+PZQ组抗血吸虫病的抢先作用最好。Fc-NPC,Ag-NPC和Fc-AgNPC可拮抗PZQ效应,所述效应在所有测试参数的改善中观察到。研究表明，植物化学物质纳米颗粒组对受感染小鼠的健康有改善作用。
