METHODS: This is a narrative review of relevant papers identified from searches of PubMed and online journals.
RESULTS: Sites of new bone growth in the enthesis were identified in patients with DISH, with likely cellular targets for growth factors being mesenchymal stem cells in the outer part of the enthesis. Similar undifferentiated skeletal stem cells are present in the outer annulus fibrosis and in the bony eminences of vertebral bodies and other bones, with the potential for response to growth factors.
CONCLUSIONS: Mesenchymal stem cells are present in specific entheseal and bony locations that are likely responsive to putative growth factors leading to new bone formation characteristic of DISH. Further study of these regions in the context of metabolic abnormalities in DISH will allow for better understanding of the pathophysiology of this common condition.
方法:这是对从PubMed和在线期刊搜索中确定的相关论文的叙述性综述。
结果:在DISH患者中发现了新骨生长的部位,生长因子的可能的细胞靶标是在外面的间充质干细胞。类似的未分化的骨骼干细胞存在于外环纤维化和椎体和其他骨骼的骨隆起中。具有对生长因子做出反应的潜力。
结论:间充质干细胞存在于特定的表面和骨性部位,可能对推定的生长因子产生反应,导致DISH的新骨形成特征。在DISH代谢异常的背景下对这些区域的进一步研究将允许更好地理解这种常见病症的病理生理学。