Abstract：
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a seriously increasing liver disorder affecting nearly 32% of adults globally. Hepatic triglycerides (TG) accumulation is the hallmark of MASLD, which results from dysregulated lipid and fatty acid uptake, increased de novo lipogenesis (DNL), and decreased lipid removal. More recently, selective autophagy of lipid droplets (LDs), termed lipophagy, has emerged to be closely associated with disrupted hepatic lipid homeostasis. Recent studies have indicated that a series of natural products have shown promise as an alternative approach in attenuating MASLD via regulating lipophagy in vivo and in vitro. Therefore, lipophagy could be a new approach for natural products to be used to improve MASLD. This article aims to provide a comprehensive overview on the interrelationship between dysregulated lipid metabolism, lipophagy, and MASLD pathogenesis. In addition, the role of some natural products as lipophagy modulators and their impact on MASLD will be discussed.
摘要：
代谢功能障碍相关脂肪变性肝病（MASLD），以前称为非酒精性脂肪性肝病（NAFLD），是一种严重增加的肝脏疾病，影响全球近32％的成年人。肝甘油三酯（TG）的积累是MASLD的标志，这是由脂质和脂肪酸摄取失调引起的，从头脂肪形成增加（DNL），和减少脂质去除。最近,选择性自噬的脂滴（LDs），称为吸脂症，已经发现与肝脏脂质稳态的破坏密切相关。最近的研究表明，一系列天然产物已显示出有望通过体内和体外调节脂质吞噬来减弱MASLD的替代方法。因此,吸脂法可能是天然产物用于改善MASLD的一种新方法。本文旨在全面概述脂质代谢失调之间的相互关系，吸脂症,和MASLD发病机制。此外,将讨论一些天然产物作为脂质吞噬调节剂的作用及其对MASLD的影响。
