Abstract：
BACKGROUND: Depression is closely related to suicidal ideation (SI); however, it is unclear who is most vulnerable to SI within the context of depression. Research suggests that individual differences in emotion reactivity and regulation may be potential moderators of the link between depression and SI. Therefore, the current study tested this hypothesis using objective markers of emotion reactivity and volitional cognitive regulation capacity during functional magnetic resonance imaging (fMRI).
METHODS: Adults (n = 91) with active SI completed validated self-report measures of current depressive symptoms and SI severity. Participants completed an fMRI task designed to probe neural response to aversive stimuli and during cognitive reappraisal - a form of volitional emotion regulation. Activation of the amygdala during aversive emotion reactivity was measured. Activation of ventrolateral, dorsolateral, and dorsomedial prefrontal cortex (vlPFC, dlPFC, and dmPFC) during cognitive reappraisal were also measured. A series of hierarchical linear regressions testing the unique and interactive effects of depression symptoms and neural activation on severity of SI were conducted.
RESULTS: Analyses revealed a depression x amygdala activation interaction. The positive association between depression and SI severity was more robust in the context of high amygdala reactivity than low amygdala reactivity. Analyses also indicated there was no PFC activity (neural cognitive reappraisal) by depression interaction.
CONCLUSIONS: Psychoactive medications were allowed and all participants endorsed suicidal intent.
CONCLUSIONS: Strategies aimed at targeting exaggerated emotion reactivity within the context of depression may be beneficial.
METHODS: Adults (n = 91) with active SI completed validated self-report measures of current depressive symptoms and SI severity. Participants completed an fMRI task designed to probe neural response to aversive stimuli and during cognitive reappraisal - a form of volitional emotion regulation. Activation of the amygdala during aversive emotion reactivity was measured. Activation of ventrolateral, dorsolateral, and dorsomedial prefrontal cortex (vlPFC, dlPFC, and dmPFC) during cognitive reappraisal were also measured. A series of hierarchical linear regressions testing the unique and interactive effects of depression symptoms and neural activation on severity of SI were conducted.
RESULTS: Analyses revealed a depression x amygdala activation interaction. The positive association between depression and SI severity was more robust in the context of high amygdala reactivity than low amygdala reactivity. Analyses also indicated there was no PFC activity (neural cognitive reappraisal) by depression interaction.
CONCLUSIONS: Psychoactive medications were allowed and all participants endorsed suicidal intent.
CONCLUSIONS: Strategies aimed at targeting exaggerated emotion reactivity within the context of depression may be beneficial.
摘要：
背景：抑郁症与自杀意念（SI）密切相关；然而，目前尚不清楚在抑郁症背景下谁最容易患SI.研究表明，情绪反应性和调节方面的个体差异可能是抑郁与SI之间联系的潜在调节因素。因此,本研究使用功能磁共振成像(fMRI)过程中情绪反应性和意志认知调节能力的客观标志物检验了这一假设.
方法：患有活动性SI的成年人（n=91）完成了当前抑郁症状和SI严重程度的有效自我报告测量。参与者完成了一项功能磁共振成像任务，旨在探索神经对厌恶刺激的反应以及在认知重新评估期间-一种自愿情绪调节形式。测量了厌恶情绪反应过程中杏仁核的激活。腹外侧活化,背外侧,和背侧前额叶皮质(vlPFC，dlPFC,还测量了认知重估期间的dmPFC）。进行了一系列分层线性回归，以测试抑郁症状和神经激活对SI严重程度的独特和交互影响。
结果：分析显示抑郁症与杏仁核激活相互作用。在杏仁核反应性高的情况下，抑郁与SI严重程度之间的正相关比杏仁核反应性低的情况更牢固。分析还表明，抑郁症的相互作用没有PFC活动（神经认知重新评估）。
结论：允许使用精神活性药物，所有参与者都认可自杀意图。
结论：针对抑郁背景下情绪反应过度的策略可能是有益的。
方法：患有活动性SI的成年人（n=91）完成了当前抑郁症状和SI严重程度的有效自我报告测量。参与者完成了一项功能磁共振成像任务，旨在探索神经对厌恶刺激的反应以及在认知重新评估期间-一种自愿情绪调节形式。测量了厌恶情绪反应过程中杏仁核的激活。腹外侧活化,背外侧,和背侧前额叶皮质(vlPFC，dlPFC,还测量了认知重估期间的dmPFC）。进行了一系列分层线性回归，以测试抑郁症状和神经激活对SI严重程度的独特和交互影响。
结果：分析显示抑郁症与杏仁核激活相互作用。在杏仁核反应性高的情况下，抑郁与SI严重程度之间的正相关比杏仁核反应性低的情况更牢固。分析还表明，抑郁症的相互作用没有PFC活动（神经认知重新评估）。
结论：允许使用精神活性药物，所有参与者都认可自杀意图。
结论：针对抑郁背景下情绪反应过度的策略可能是有益的。
