Abstract：
OBJECTIVE: To evaluate the differences between audio-vestibular function testing and inner ear gadolinium magnetic resonance imaging (MRI) in distinguishing definite Ménière disease (DMD) and probable Ménière disease (PMD), and to provide a reference for early clinical diagnosis and intervention.
METHODS: A total of 116 patients diagnosed with DMD (n = 80) and PMD (n = 36) were enrolled. The differences in the results of pure tone audiometry, caloric test, and tympanic injection of gadolinium for contrast-enhanced MRI between the two groups were compared and analyzed. Parameters that could differentiate between the two conditions were identified, and the sensitivity and specificity and the area under the curve (AUC) of individual and combined indices in the differential diagnosis of DMD and PMD were evaluated.
RESULTS: The hearing threshold and hearing asymmetry rate of the DMD group were significantly higher than those of the PMD group (p < 0.001), 98.8% and 30.6%, respectively. The abnormal rates of canal paresis (CP) and severity of endolymphatic hydrops in the DMD group were higher than those in the PMD group (p < 0.05). When combined with high-frequency hearing thresholds, hearing asymmetry, hearing curve type, endolymphatic hydrops, and abnormal CP, the diagnostic accuracy of DMD was improved compared to using high-frequency alone (p < 0.05).
CONCLUSIONS: This study showed that PMD and DMD may represent two different stages in the development of MD disease. The comprehensive assessment of audio-vestibular function testing and inner ear MRI proves beneficial for early diagnosis, potentially contributing to the preservation of inner ear function.
METHODS: A total of 116 patients diagnosed with DMD (n = 80) and PMD (n = 36) were enrolled. The differences in the results of pure tone audiometry, caloric test, and tympanic injection of gadolinium for contrast-enhanced MRI between the two groups were compared and analyzed. Parameters that could differentiate between the two conditions were identified, and the sensitivity and specificity and the area under the curve (AUC) of individual and combined indices in the differential diagnosis of DMD and PMD were evaluated.
RESULTS: The hearing threshold and hearing asymmetry rate of the DMD group were significantly higher than those of the PMD group (p < 0.001), 98.8% and 30.6%, respectively. The abnormal rates of canal paresis (CP) and severity of endolymphatic hydrops in the DMD group were higher than those in the PMD group (p < 0.05). When combined with high-frequency hearing thresholds, hearing asymmetry, hearing curve type, endolymphatic hydrops, and abnormal CP, the diagnostic accuracy of DMD was improved compared to using high-frequency alone (p < 0.05).
CONCLUSIONS: This study showed that PMD and DMD may represent two different stages in the development of MD disease. The comprehensive assessment of audio-vestibular function testing and inner ear MRI proves beneficial for early diagnosis, potentially contributing to the preservation of inner ear function.
摘要：
目的：评估音频前庭功能测试和内耳钆磁共振成像（MRI）在区分明确的梅尼埃病（DMD）和可能的梅尼埃病（PMD）方面的差异。为临床早期诊断和干预提供参考。
方法：共纳入116例诊断为DMD（n=80）和PMD（n=36）的患者。纯音测听结果的差异，热量测试,对比分析两组患者鼓室注射钆进行MRI增强扫描的效果。确定了可以区分这两种条件的参数，评价各指标及联合指标在DMD与PMD鉴别诊断中的敏感性、特异性及曲线下面积(AUC)。
结果：DMD组的听阈和听力不对称率明显高于PMD组（p<0.001），98.8%和30.6%，分别。DMD组的管麻痹（CP）异常率和内淋巴水肿的严重程度高于PMD组（p<0.05）。当与高频听阈结合时，听力不对称，听力曲线类型,内淋巴积液,和异常CP，与单独使用高频相比,DMD的诊断准确性提高(p<0.05).
结论：这项研究表明，PMD和DMD可能代表MD疾病发展的两个不同阶段。音频前庭功能测试和内耳MRI的综合评估证明有利于早期诊断，可能有助于保护内耳功能。
方法：共纳入116例诊断为DMD（n=80）和PMD（n=36）的患者。纯音测听结果的差异，热量测试,对比分析两组患者鼓室注射钆进行MRI增强扫描的效果。确定了可以区分这两种条件的参数，评价各指标及联合指标在DMD与PMD鉴别诊断中的敏感性、特异性及曲线下面积(AUC)。
结果：DMD组的听阈和听力不对称率明显高于PMD组（p<0.001），98.8%和30.6%，分别。DMD组的管麻痹（CP）异常率和内淋巴水肿的严重程度高于PMD组（p<0.05）。当与高频听阈结合时，听力不对称，听力曲线类型,内淋巴积液,和异常CP，与单独使用高频相比,DMD的诊断准确性提高(p<0.05).
结论：这项研究表明，PMD和DMD可能代表MD疾病发展的两个不同阶段。音频前庭功能测试和内耳MRI的综合评估证明有利于早期诊断，可能有助于保护内耳功能。
