OPA1 通过增加线粒体 ROS 和抑制综合应激反应来促进铁凋亡。
关键词: ATF4 GPx4 OPA1 cell death ferroptosis integrated stress response mitochondria system X(c)(−) xCT
Mesh : GTP Phosphohydrolases / metabolism genetics Ferroptosis / genetics Animals Reactive Oxygen Species / metabolism Humans Mitochondria / metabolism genetics Activating Transcription Factor 4 / metabolism genetics Mitochondrial Dynamics Mice Mice, Knockout Oxidative Stress Signal Transduction Lipid Peroxidation Mutation
来 源:
DOI:10.1016/j.molcel.2024.07.020
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