METHODS: A meta-analysis of 29 studies involving 785 participants was conducted. The effects of genuine and sham DLPFC-tES on pain perception were examined in healthy individuals and patients with clinical pain. Subgroup analyses explored the impact of stimulation parameters and pain modalities.
RESULTS: DLPFC-tES did not significantly affect pain outcomes in healthy populations but showed promise in reducing pain-intensity ratings in patients with clinical pain (Hedges\' g = -0.78, 95% CI = [-1.33, -0.24], p = 0.005). Electrode placement significantly influenced the analgesic effect, with better results observed when the anode was at F3 and the cathode at F4.
CONCLUSIONS: DLPFC-tES holds potential as a cost-effective pain management option, particularly for clinical populations. Optimizing electrode placement, especially with an symmetrical configuration, may enhance therapeutic efficacy. These findings underscore the promise of DLPFC-tES for alleviating perceived pain intensity in clinical settings, emphasizing the importance of electrode placement optimization.
方法:对涉及785名参与者的29项研究进行了荟萃分析。在健康个体和临床疼痛患者中检查了真正的和假的DLPFC-tES对疼痛感知的影响。亚组分析探讨了刺激参数和疼痛模式的影响。
结果:DLPFC-tES对健康人群的疼痛结局没有显著影响,但在降低临床疼痛患者的疼痛强度评分方面显示出希望(Hedges\'g=-0.78,95%CI=[-1.33,-0.24],p=0.005)。电极放置显著影响镇痛效果,当阳极在F3且阴极在F4时观察到更好的结果。
结论:DLPFC-tES具有作为一种具有成本效益的疼痛管理选择的潜力,特别是临床人群。优化电极位置,尤其是在对称配置的情况下,可以增强治疗效果。这些发现强调了DLPFC-tES在临床环境中减轻疼痛强度的前景。强调电极位置优化的重要性。