设计,含有 NHC - Au ( I ) 络合物和咔唑部分的多靶标杂化分子的合成和生物学评估。
关键词: Anti-inflammatory Anticancer Antioxidant Hybrid molecules N-alkylthiolated carbazoles N-heterocyclic carbenes
Mesh : Carbazoles / chemistry pharmacology chemical synthesis Humans Drug Design Antineoplastic Agents / pharmacology chemistry chemical synthesis Heterocyclic Compounds / chemistry pharmacology chemical synthesis Structure-Activity Relationship Methane / analogs & derivatives chemistry pharmacology Molecular Structure Gold / chemistry pharmacology Drug Screening Assays, Antitumor Cell Line, Tumor Cell Proliferation / drug effects Antioxidants / pharmacology chemistry chemical synthesis Animals Dose-Response Relationship, Drug Coordination Complexes / pharmacology chemistry chemical synthesis Mice Anti-Inflammatory Agents / pharmacology chemistry chemical synthesis
来 源: DOI:10.1016/j.ejmech.2024.116757