PDF(Pubmed)
Abstract：
Skeletal muscle has gained recognition as an endocrine organ releasing myokines upon contraction during physical exercise. These myokines exert both local and pleiotropic health benefits, underscoring the crucial role of muscle function in countering obesity and contributing to the overall positive effects of exercise on health. Here, we found that exercise activates muscle p38γ, increasing locomotor activity through the secretion of interleukin-15 (IL-15). IL-15 signals in the motor cortex, stimulating locomotor activity. This activation of muscle p38γ, leading to an increase locomotor activity, plays a crucial role in reducing the risk of diabetes and liver steatosis, unveiling a vital muscle-brain communication pathway with profound clinical implications. The correlation between p38γ activation in human muscle during acute exercise and increased blood IL-15 levels highlights the potential therapeutic relevance of this pathway in treating obesity and metabolic diseases. These findings provide valuable insights into the molecular basis of exercise-induced myokine responses promoting physical activity.
摘要：
骨骼肌已被公认为在体育锻炼期间收缩时释放肌细胞的内分泌器官。这些肌细胞发挥局部和多效性的健康益处，强调肌肉功能在对抗肥胖和促进运动对健康的整体积极影响方面的关键作用。这里,我们发现运动激活肌肉p38γ，通过分泌白细胞介素-15（IL-15）增加运动活性。运动皮层中的IL-15信号,刺激运动活动。这种肌肉p38γ的激活，导致运动活动增加，在降低糖尿病和肝脏脂肪变性的风险中起着至关重要的作用，揭示了一条具有深远临床意义的重要肌肉-大脑交流途径。急性运动期间人肌肉中的p38γ激活与血液IL-15水平升高之间的相关性突出了该途径在治疗肥胖和代谢疾病中的潜在治疗相关性。这些发现为运动诱导的促进身体活动的肌细胞反应的分子基础提供了有价值的见解。
