Abstract：
Conventional systemic cancer therapy often causes numerous adverse events. However, discovering overexpressed folate receptors in solid tumours has paved the way for targeted chemotherapy. Folic acid (FA), a ligand for these receptors, is frequently combined with chemotherapeutic drugs to improve their effectiveness. Carbon nanotubes have emerged as a versatile and promising method for delivering these folate-conjugated nano-systems, ensuring targeted delivery of therapeutic agents to cancerous cells. When FA-conjugated nanotubes dissociate, they release the drug-loaded nanotubes inside the malignant cells, reducing off-target effects. These nanotubes can also be used for combination therapies, producing synergistic effects. This review aims to comprehensively gather and critically evaluate the latest methods for delivering therapeutics using FA-conjugated nanovehicles. Additionally, it seeks to enhance our comprehension of the pertinent chemistry and biochemical pathways involved in this approach.
摘要：
常规的系统性癌症治疗通常会导致许多不良事件。然而,在实体肿瘤中发现过度表达的叶酸受体为靶向化疗铺平了道路.叶酸(FA),这些受体的配体，经常与化疗药物联合使用以提高其有效性。碳纳米管已成为提供这些叶酸共轭纳米系统的通用且有前途的方法，确保治疗剂靶向递送至癌细胞。当FA共轭纳米管解离时，它们在恶性细胞内释放装载药物的纳米管，减少脱靶效应。这些纳米管也可用于联合治疗，产生协同效应。这篇综述旨在全面收集和批判性地评估使用FA缀合的纳米载体提供治疗的最新方法。此外,它旨在增强我们对这种方法所涉及的相关化学和生化途径的理解。
