Abstract：
This study aimed to investigate the antioxidant and anti-inflammatory properties of quercetin on the cellular components of the Enteric Nervous System in the ileum of rats with arthritis. Rats were distributed into five groups: control (C), arthritic (AIA), arthritic treated with ibuprofen (AI), arthritic treated with quercetin (AQ) and arthritic treated with both ibuprofen and quercetin (AIQ). The ileum was processed for immunohistochemical techniques for HuC/D, calcitonin gene-related peptide, and vasoactive intestinal polypeptide. Measurements in histological sections, chemiluminescence assays, and total antioxidant capacity were also performed. Rheumatoid arthritis resulted in a decrease in neuronal density, yet neuroplasticity mechanisms were evident through observed changes in varicosities size and neuronal area compared to the control group. Reduced paw edema and neuroprotective effects were predominantly noted in both plexuses, as evidenced by the increased density preservation of HuC/D-IR neurons in the AIQ group. The increase of lipoperoxidation levels and paw edema volume in the AQ group was observed compared to the arthritic, whereas the AIQ group mainly showed similar results to those observed in the control. The enteropathy associated with arthritis proved to be significant in the field of gastroenterology, and the combination of quercetin and ibuprofen demonstrated promising anti-inflammatory and neuroprotective effects.
摘要：
本研究旨在探讨槲皮素对关节炎大鼠回肠肠神经系统细胞成分的抗氧化和抗炎作用。大鼠分为5组:对照组(C),关节炎（AIA），用布洛芬（AI）治疗关节炎，用槲皮素（AQ）治疗关节炎，用布洛芬和槲皮素（AIQ）治疗关节炎。回肠被处理用于HuC/D的免疫组织化学技术,降钙素基因相关肽，和血管活性肠多肽。组织学切片的测量，化学发光测定，和总抗氧化能力也被执行。类风湿性关节炎导致神经元密度降低，然而，通过观察到的静脉曲张大小和神经元面积的变化，与对照组相比，神经可塑性机制是明显的。在两个神经丛中主要注意到减少的爪水肿和神经保护作用，AIQ组中HuC/D-IR神经元的密度保存增加证明了这一点。与关节炎相比，AQ组的脂质过氧化水平和爪水肿体积增加，而AIQ组主要显示与对照组相似的结果。与关节炎相关的肠病在胃肠病学领域被证明是重要的，槲皮素和布洛芬的组合显示出有希望的抗炎和神经保护作用。
