PDF(Pubmed)
Abstract：
With the increasingly severe situation of obesity and population aging, there is growing concern about sarcopenia obesity (SO). SO refers to the coexistence of obesity and sarcopenia, which imposes a heavier burden on individuals and society compared to obesity or sarcopenia alone. Therefore, comprehending the pathogenesis of SO and implementing effective clinical interventions are vital for its prevention and treatment. This review uses a comprehensive literature search and analysis of PubMed, Web of Science, and CNKI databases, with search terms including \"Sarcopenic obesity\", \"exercise\", \"cytokines\", \"inflammation\", \"mitochondrial quality control\", and \"microRNA\", covering relevant studies published up to July 2024. The results indicate that the pathogenesis of SO is complex, involving mechanisms like age-related changes in body composition, hormonal alterations, inflammation, mitochondrial dysfunction, and genetic and epigenetic factors. Regarding exercise interventions for SO, aerobic exercise can reduce fat mass, resistance exercise can increase skeletal muscle mass and strength, and combined exercise can achieve both, making it the optimal intervention for SO. The potential mechanisms by which exercise may prevent and treat SO include regulating cytokine secretion, inhibiting inflammatory pathways, improving mitochondrial quality, and mediating microRNA expression. This review emphasizes the effectiveness of exercise interventions in mitigating sarcopenic obesity through comprehensive analysis of its multifactorial pathogenesis and the mechanistic insights into exercise\'s therapeutic effects. Understanding these mechanisms informs targeted therapeutic strategies aimed at alleviating the societal and individual burdens associated with SO.
摘要：
随着肥胖和人口老龄化形势的日益严峻,人们越来越关注肌肉减少症（SO）。SO是指肥胖和肌少症并存,与单纯肥胖或肌少症相比，这给个人和社会带来了更沉重的负担。因此,了解SO的发病机制，实施有效的临床干预措施，对其预防和治疗至关重要。这篇综述采用了对PubMed的全面文献检索和分析，WebofScience,和CNKI数据库，搜索字词包括“肌肉减少性肥胖”，\"练习\",“细胞因子”，\"炎症\",“线粒体质量控制”，和“microRNA”，涵盖截至2024年7月发表的相关研究。结果表明SO的发病机制复杂,涉及与年龄相关的身体成分变化等机制，荷尔蒙的改变,炎症,线粒体功能障碍，遗传和表观遗传因素。关于SO的锻炼干预，有氧运动可以减少脂肪量，抗阻运动可以增加骨骼肌质量和力量，联合锻炼可以实现这两者，使其成为SO的最佳干预措施。运动可以预防和治疗SO的潜在机制包括调节细胞因子分泌，抑制炎症途径，提高线粒体质量，和介导microRNA表达。本综述通过综合分析肌少症肥胖的多因素发病机制和对运动治疗效果的机制见解，强调运动干预在减轻肌少症肥胖方面的有效性。了解这些机制可以提供针对性的治疗策略，旨在减轻与SO相关的社会和个人负担。
