Abstract：
The sequelae of post-coronavirus disease 2019 (COVID-19) pneumonia on lung function, exercise capacity, and quality of life were observed in both short-term and long-term. However, the study about the respiratory and locomotor muscle strength in severe and critically ill COVID-19 survivors are still limited. Therefore, we aimed to examine long-term pulmonary function, functional capacities, and respiratory and locomotor body muscle strength in severe to critically ill post-COVID-19 survivors.
A prospective observational study was conducted in twenty-two post-COVID-19 pneumonia and healthy adults. Clinical characteristics during admission, pulmonary function, functional capacity, respiratory muscles, and locomotor muscles strength were examined at 1, 3, and 6 months after discharge from the hospital.
The generalized linear mixed model showed that percent predicted of forced expiratory volume in the first second (%FEV1), percent predicted of forced vital capacity (%FVC), maximum inspiratory pressure (MIP), handgrip strength, six-minute walk distance (6-MWD), and 5-times sit to stand (5TSTS) were significantly lower in post-COVID-19 pneumonia patients than in healthy subjects during the follow-up period. The percent predicted of maximal voluntary ventilation (%MVV), and locomotor muscle strength were not different between the two groups throughout the follow-up period. Among post-COVID-19 pneumonia patients, %FEV1, %FVC, %MVV, 5TSTS, locomotor muscle strength significantly improved at three months compared to baseline at one month.
Pulmonary function, functional capacity, respiratory, and locomotor muscle strength of survivors from COVID-19 were impaired and recovery was observed after three to six months. These emphasized the need to evaluate the long-term consequences of COVID-19.
A prospective observational study was conducted in twenty-two post-COVID-19 pneumonia and healthy adults. Clinical characteristics during admission, pulmonary function, functional capacity, respiratory muscles, and locomotor muscles strength were examined at 1, 3, and 6 months after discharge from the hospital.
The generalized linear mixed model showed that percent predicted of forced expiratory volume in the first second (%FEV1), percent predicted of forced vital capacity (%FVC), maximum inspiratory pressure (MIP), handgrip strength, six-minute walk distance (6-MWD), and 5-times sit to stand (5TSTS) were significantly lower in post-COVID-19 pneumonia patients than in healthy subjects during the follow-up period. The percent predicted of maximal voluntary ventilation (%MVV), and locomotor muscle strength were not different between the two groups throughout the follow-up period. Among post-COVID-19 pneumonia patients, %FEV1, %FVC, %MVV, 5TSTS, locomotor muscle strength significantly improved at three months compared to baseline at one month.
Pulmonary function, functional capacity, respiratory, and locomotor muscle strength of survivors from COVID-19 were impaired and recovery was observed after three to six months. These emphasized the need to evaluate the long-term consequences of COVID-19.
摘要：
背景：2019年冠状病毒病后（COVID-19）肺炎的后遗症对肺功能的影响，锻炼能力,观察短期和长期生活质量。然而,关于重症和危重症COVID-19幸存者呼吸和运动肌力的研究仍然有限。因此,我们的目的是检查长期肺功能，功能能力，重症至重症COVID-19后幸存者的呼吸和运动肌力。
方法：对22例COVID-19后肺炎和健康成人进行了一项前瞻性观察性研究。入院期间的临床特征，肺功能,功能能力，呼吸肌,出院后1、3和6个月检查运动肌肉力量。
结果：广义线性混合模型显示，第一秒用力呼气量的预测百分比（％FEV1），预测的强制肺活量百分比(%FVC)，最大吸气压力(MIP),握力,六分钟步行距离(6-MWD)在随访期间，COVID-19后肺炎患者的5次坐着站立（5TSTS）显着低于健康受试者。预测的最大自愿通气百分比(%MVV)，在整个随访期间，两组之间的运动肌力没有差异。在COVID-19后肺炎患者中，%FEV1,%FVC,%MVV,5TSTS,与1个月时的基线相比,3个月时的运动肌力显著改善.
结论：肺功能，功能能力，呼吸,COVID-19幸存者的运动肌力受损，3至6个月后观察到恢复。这些强调了评估COVID-19长期后果的必要性。
方法：对22例COVID-19后肺炎和健康成人进行了一项前瞻性观察性研究。入院期间的临床特征，肺功能,功能能力，呼吸肌,出院后1、3和6个月检查运动肌肉力量。
结果：广义线性混合模型显示，第一秒用力呼气量的预测百分比（％FEV1），预测的强制肺活量百分比(%FVC)，最大吸气压力(MIP),握力,六分钟步行距离(6-MWD)在随访期间，COVID-19后肺炎患者的5次坐着站立（5TSTS）显着低于健康受试者。预测的最大自愿通气百分比(%MVV)，在整个随访期间，两组之间的运动肌力没有差异。在COVID-19后肺炎患者中，%FEV1,%FVC,%MVV,5TSTS,与1个月时的基线相比,3个月时的运动肌力显著改善.
结论：肺功能，功能能力，呼吸,COVID-19幸存者的运动肌力受损，3至6个月后观察到恢复。这些强调了评估COVID-19长期后果的必要性。
