PDF(Pubmed)
Abstract：
BACKGROUND: Increasing studies have reported a causal relationship between androgenetic alopecia (AGA) and lipid-related metabolites. However, the relationships between HDL-C, LDL-C, Omega-6, and Omega-3 with AGA remain unclear. Some research findings are even contradictory. Therefore, we designed this study to explore this issue.
METHODS: In this study, we selected seven exposure factors, screened SNPs with significant associations, removed linkage disequilibrium and weak instrumental variables, and conducted bidirectional MR analysis.
RESULTS: The study found that omega-6 and LDL-C, especially total cholesterol in medium LDL and total cholesterol in small LDL, are risk factors for the occurrence of androgenetic alopecia.
CONCLUSIONS: In summary, we found that various lipid-related metabolites have a causal relationship with the occurrence of androgenetic alopecia, providing new insights into the pathogenesis of androgenetic alopecia and offering references for clinical treatment of androgenetic alopecia.
METHODS: In this study, we selected seven exposure factors, screened SNPs with significant associations, removed linkage disequilibrium and weak instrumental variables, and conducted bidirectional MR analysis.
RESULTS: The study found that omega-6 and LDL-C, especially total cholesterol in medium LDL and total cholesterol in small LDL, are risk factors for the occurrence of androgenetic alopecia.
CONCLUSIONS: In summary, we found that various lipid-related metabolites have a causal relationship with the occurrence of androgenetic alopecia, providing new insights into the pathogenesis of androgenetic alopecia and offering references for clinical treatment of androgenetic alopecia.
摘要：
背景：越来越多的研究报道了雄激素性脱发（AGA）与脂质相关代谢物之间的因果关系。然而,HDL-C之间的关系，LDL-C,Omega-6和Omega-3与AGA仍不清楚。有些研究结果甚至是矛盾的。因此,我们设计了这项研究来探讨这个问题。
方法：在本研究中，我们选择了七个暴露因素，筛选出具有显著关联的SNP，消除了连锁不平衡和弱工具变量，并进行了双向MR分析。
结果：研究发现，Omega-6和LDL-C，尤其是中等LDL中的总胆固醇和小LDL中的总胆固醇，是雄激素性脱发发生的危险因素。
结论：总之，我们发现各种脂质相关代谢产物与雄激素性脱发的发生有因果关系,为雄激素性脱发的发病机制提供新的见解，为雄激素性脱发的临床治疗提供参考。
方法：在本研究中，我们选择了七个暴露因素，筛选出具有显著关联的SNP，消除了连锁不平衡和弱工具变量，并进行了双向MR分析。
结果：研究发现，Omega-6和LDL-C，尤其是中等LDL中的总胆固醇和小LDL中的总胆固醇，是雄激素性脱发发生的危险因素。
结论：总之，我们发现各种脂质相关代谢产物与雄激素性脱发的发生有因果关系,为雄激素性脱发的发病机制提供新的见解，为雄激素性脱发的临床治疗提供参考。
