METHODS: In this study, we selected seven exposure factors, screened SNPs with significant associations, removed linkage disequilibrium and weak instrumental variables, and conducted bidirectional MR analysis.
RESULTS: The study found that omega-6 and LDL-C, especially total cholesterol in medium LDL and total cholesterol in small LDL, are risk factors for the occurrence of androgenetic alopecia.
CONCLUSIONS: In summary, we found that various lipid-related metabolites have a causal relationship with the occurrence of androgenetic alopecia, providing new insights into the pathogenesis of androgenetic alopecia and offering references for clinical treatment of androgenetic alopecia.
方法:在本研究中,我们选择了七个暴露因素,筛选出具有显著关联的SNP,消除了连锁不平衡和弱工具变量,并进行了双向MR分析。
结果:研究发现,Omega-6和LDL-C,尤其是中等LDL中的总胆固醇和小LDL中的总胆固醇,是雄激素性脱发发生的危险因素。
结论:总之,我们发现各种脂质相关代谢产物与雄激素性脱发的发生有因果关系,为雄激素性脱发的发病机制提供新的见解,为雄激素性脱发的临床治疗提供参考。