%0 Journal Article
%T Causal effects of omega-6 and LDL-C on androgenetic alopecia: A Mendelian randomization study.
%A Peilong L
%A Quanlin Z
%A Shuqing G
%J Skin Res Technol
%V 30
%N 8
%D 2024 Aug
%M 39138832
%F 2.24
%R 10.1111/srt.70000
%X <B>BACKGROUND: </B>Increasing studies have reported a causal relationship between androgenetic alopecia (AGA) and lipid-related metabolites. However, the relationships between HDL-C, LDL-C, Omega-6, and Omega-3 with AGA remain unclear. Some research findings are even contradictory. Therefore, we designed this study to explore this issue.<BR><B>METHODS: </B>In this study, we selected seven exposure factors, screened SNPs with significant associations, removed linkage disequilibrium and weak instrumental variables, and conducted bidirectional MR analysis.<BR><B>RESULTS: </B>The study found that omega-6 and LDL-C, especially total cholesterol in medium LDL and total cholesterol in small LDL, are risk factors for the occurrence of androgenetic alopecia.<BR><B>CONCLUSIONS: </B>In summary, we found that various lipid-related metabolites have a causal relationship with the occurrence of androgenetic alopecia, providing new insights into the pathogenesis of androgenetic alopecia and offering references for clinical treatment of androgenetic alopecia.