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Abstract：
BACKGROUND: Acute coronary syndrome (ACS) is a serious cardiovascular disease that severely affects the quality of life and longevity of patients. MicroRNAs (miRNAs) play a key role in the progression of ACS with significant clinical value. The aim of this study was to examine the clinical value of miR-223-5p in ACS and on the occurrence of major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI).
METHODS: The plasma expression of miR-223-5p was detected by RT-qPCR. The correlation of miR-223-5p and cTnI or Gensini score was shown by the Pearson method. Risk factors for the development of ACS were analyzed by multivariate logistic regression. The efficacy of miR-223-5p in identifying patients with ACS was shown by ROC curve. The predictive value of miR-223-5p for MACE development in ACS patients within 6 months after PCI was assessed by Kaplan-Meier curve and multivariate Cox regression.
RESULTS: miR-223-5p levels were markedly elevated in ACS patients. miR-223-5p was found to be positively related to cTnI or Gensini score. miR-223-5p was a risk factor for ACS and significantly identified patients with ACS. MACE was more likely to occur after PCI in patients with high miR-223-5p levels, and miR-223-5p was an independent prognostic indicator of MACE.
CONCLUSIONS: miR-223-5p had diagnostic value for ACS and predicted MACE after PCI.
METHODS: The plasma expression of miR-223-5p was detected by RT-qPCR. The correlation of miR-223-5p and cTnI or Gensini score was shown by the Pearson method. Risk factors for the development of ACS were analyzed by multivariate logistic regression. The efficacy of miR-223-5p in identifying patients with ACS was shown by ROC curve. The predictive value of miR-223-5p for MACE development in ACS patients within 6 months after PCI was assessed by Kaplan-Meier curve and multivariate Cox regression.
RESULTS: miR-223-5p levels were markedly elevated in ACS patients. miR-223-5p was found to be positively related to cTnI or Gensini score. miR-223-5p was a risk factor for ACS and significantly identified patients with ACS. MACE was more likely to occur after PCI in patients with high miR-223-5p levels, and miR-223-5p was an independent prognostic indicator of MACE.
CONCLUSIONS: miR-223-5p had diagnostic value for ACS and predicted MACE after PCI.
摘要：
背景：急性冠状动脉综合征（ACS）是一种严重的心血管疾病，严重影响患者的生活质量和寿命。MicroRNAs(miRNAs)在ACS的进展中起着重要的作用,具有重要的临床价值。这项研究的目的是检查miR-223-5p在ACS中的临床价值以及经皮冠状动脉介入治疗（PCI）后主要不良心血管事件（MACE）的发生。
方法：采用RT-qPCR检测血浆中miR-223-5p的表达。通过Pearson方法显示miR-223-5p与cTnI或Gensini评分的相关性。采用多因素logistic回归分析ACS发生的危险因素。通过ROC曲线显示miR-223-5p在识别ACS患者中的功效。通过Kaplan-Meier曲线和多变量Cox回归评估miR-223-5p对ACS患者PCI术后6个月内发生MACE的预测价值。
结果：miR-223-5p水平在ACS患者中显著升高。miR-223-5p与cTnI或Gensini评分呈正相关。miR-223-5p是ACS的危险因素，并可显著识别ACS患者。高miR-223-5p水平的患者在PCI后更容易发生MACE，miR-223-5p是MACE的独立预后指标。
结论：miR-223-5p对ACS和PCI术后MACE具有诊断价值。
方法：采用RT-qPCR检测血浆中miR-223-5p的表达。通过Pearson方法显示miR-223-5p与cTnI或Gensini评分的相关性。采用多因素logistic回归分析ACS发生的危险因素。通过ROC曲线显示miR-223-5p在识别ACS患者中的功效。通过Kaplan-Meier曲线和多变量Cox回归评估miR-223-5p对ACS患者PCI术后6个月内发生MACE的预测价值。
结果：miR-223-5p水平在ACS患者中显著升高。miR-223-5p与cTnI或Gensini评分呈正相关。miR-223-5p是ACS的危险因素，并可显著识别ACS患者。高miR-223-5p水平的患者在PCI后更容易发生MACE，miR-223-5p是MACE的独立预后指标。
结论：miR-223-5p对ACS和PCI术后MACE具有诊断价值。
