METHODS: The plasma expression of miR-223-5p was detected by RT-qPCR. The correlation of miR-223-5p and cTnI or Gensini score was shown by the Pearson method. Risk factors for the development of ACS were analyzed by multivariate logistic regression. The efficacy of miR-223-5p in identifying patients with ACS was shown by ROC curve. The predictive value of miR-223-5p for MACE development in ACS patients within 6 months after PCI was assessed by Kaplan-Meier curve and multivariate Cox regression.
RESULTS: miR-223-5p levels were markedly elevated in ACS patients. miR-223-5p was found to be positively related to cTnI or Gensini score. miR-223-5p was a risk factor for ACS and significantly identified patients with ACS. MACE was more likely to occur after PCI in patients with high miR-223-5p levels, and miR-223-5p was an independent prognostic indicator of MACE.
CONCLUSIONS: miR-223-5p had diagnostic value for ACS and predicted MACE after PCI.
方法:采用RT-qPCR检测血浆中miR-223-5p的表达。通过Pearson方法显示miR-223-5p与cTnI或Gensini评分的相关性。采用多因素logistic回归分析ACS发生的危险因素。通过ROC曲线显示miR-223-5p在识别ACS患者中的功效。通过Kaplan-Meier曲线和多变量Cox回归评估miR-223-5p对ACS患者PCI术后6个月内发生MACE的预测价值。
结果:miR-223-5p水平在ACS患者中显著升高。miR-223-5p与cTnI或Gensini评分呈正相关。miR-223-5p是ACS的危险因素,并可显著识别ACS患者。高miR-223-5p水平的患者在PCI后更容易发生MACE,miR-223-5p是MACE的独立预后指标。
结论:miR-223-5p对ACS和PCI术后MACE具有诊断价值。