PDF(Pubmed)
Abstract：
Despite the growing interest in precision medicine-based therapies for Alzheimer\'s disease (AD), little research has been conducted on how individual AD risk factors influence changes in cognitive function following transcranial direct current stimulation (tDCS). This study evaluates the cognitive effects of sequential tDCS on 63 mild cognitive impairment (MCI) patients, considering AD risk factors such as amyloid-beta deposition, APOE ε4, BDNF polymorphism, and sex. Using both frequentist and Bayesian methods, we assessed the interaction of tDCS with these risk factors on cognitive performance. Notably, we found that amyloid-beta deposition significantly interacted with tDCS in improving executive function, specifically Stroop Word-Color scores, with strong Bayesian support for this finding. Memory enhancements were differentially influenced by BDNF Met carrier status. However, sex and APOE ε4 status did not show significant effects. Our results highlight the importance of individual AD risk factors in modulating cognitive outcomes from tDCS, suggesting that precision medicine may offer more effective tDCS treatments tailored to individual risk profiles in early AD stages.
摘要：
尽管人们对基于精准医学的阿尔茨海默病(AD)疗法越来越感兴趣，关于个体AD危险因素如何影响经颅直流电刺激（tDCS）后认知功能变化的研究很少。这项研究评估了序贯tDCS对63例轻度认知障碍（MCI）患者的认知效果。考虑到AD的危险因素，如β淀粉样蛋白沉积，APOEε4，BDNF多态性，和性爱。使用频率论和贝叶斯方法，我们评估了tDCS与这些危险因素对认知表现的交互作用.值得注意的是,我们发现β淀粉样蛋白沉积在改善执行功能方面与tDCS显著相互作用，特别是StroopWord-Color分数，对这一发现有强烈的贝叶斯支持。记忆增强受BDNFMet携带者状态的不同影响。然而,性别和APOEε4状态没有显着影响。我们的结果强调了个体AD危险因素在调节tDCS认知结果中的重要性，这表明精准医学可以提供更有效的tDCS治疗,适合AD早期个体的风险状况.
