Abstract：
Effective and less toxic therapies for medulloblastoma have proved to be highly elusive. In this issue of Cancer Cell, Yang et al. show that thyroid hormone treatment leads to the activation of neurogenic differentiation factor 1 (NeuroD1) and differentiation of medulloblastoma cells through reversing EZH2-mediated transcriptional repression of NeuroD1.
摘要：
髓母细胞瘤的有效且毒性较小的疗法已被证明是高度难以捉摸的。在本期的癌细胞中，Yangetal.表明甲状腺激素治疗通过逆转EZH2介导的NeuroD1的转录抑制导致神经源性分化因子1（NeuroD1）的激活和髓母细胞瘤细胞的分化。
