PDF(Pubmed)
Abstract：
The epigenetic layer of regulation has become increasingly relevant in the research focused on tumor suppressors. KLF4 is a well-described zinc-finger transcription factor, mainly known for its role in the acquisition of cell pluripotency. Here we report and describe the most relevant epigenetic regulation mechanisms that affect KLF4 expression in tumors. CpG island methylation emerges as the most common mechanism in several tumors including lung adenocarcinoma, hepatocellular carcinoma, non-Hodgkin lymphomas, among others. Further layers of regulation represented by histone methylation and acetylation and by non-coding RNAs are described. Overall, KLF4 emerges as a crucial target in the fight against cancer.
摘要：
表观遗传调控层在关注肿瘤抑制因子的研究中变得越来越重要。KLF4是一种很好描述的锌指转录因子，主要以其在细胞多能性获得中的作用而闻名。在这里，我们报告并描述了影响肿瘤中KLF4表达的最相关的表观遗传调控机制。CpG岛甲基化是几种肿瘤中最常见的机制，包括肺腺癌，肝细胞癌，非霍奇金淋巴瘤,在其他人中。描述了由组蛋白甲基化和乙酰化以及非编码RNA代表的其他调控层。总的来说,KLF4成为对抗癌症的关键目标。
