PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to elucidate the influences of 1p/19q co-deletion on structural connectivity alterations in patients with dominant hemisphere insular diffuse gliomas.
UNASSIGNED: We incorporated 32 cases of left insular gliomas and 20 healthy controls for this study. Using diffusion MRI, we applied correlational tractography, differential tractography, and graph theoretical analysis to explore the potential connectivity associated with 1p/19q co-deletion.
UNASSIGNED: The study revealed that the quantitative anisotropy (QA) of key deep medial fiber tracts, including the anterior thalamic radiation, superior thalamic radiation, fornix, and cingulum, had significant negative associations with 1p/19q co-deletion (FDR = 4.72 × 10-5). These tracts are crucial in maintaining the integrity of brain networks. Differential analysis further supported these findings (FWER-corrected p < 0.05). The 1p/19q non-co-deletion group exhibited significantly higher clustering coefficients (FDR-corrected p < 0.05) and reduced betweenness centrality (FDR-corrected p < 0.05) in regions around the tumor compared to HC group. Graph theoretical analysis indicated that non-co-deletion patients had increased local clustering and decreased betweenness centrality in peritumoral brain regions compared to co-deletion patients and healthy controls (FDR-corrected p < 0.05). Additionally, despite not being significant through correction, patients with 1p/19q co-deletion exhibited lower trends in weighted average clustering coefficient, transitivity, small worldness, and global efficiency, while showing higher tendencies in weighted path length compared to patients without the co-deletion.
UNASSIGNED: The findings of this study underline the significant role of 1p/19q co-deletion in altering structural connectivity in insular glioma patients. These alterations in brain networks could have profound implications for the neural functionality in patients with dominant hemisphere insular gliomas.
UNASSIGNED: We incorporated 32 cases of left insular gliomas and 20 healthy controls for this study. Using diffusion MRI, we applied correlational tractography, differential tractography, and graph theoretical analysis to explore the potential connectivity associated with 1p/19q co-deletion.
UNASSIGNED: The study revealed that the quantitative anisotropy (QA) of key deep medial fiber tracts, including the anterior thalamic radiation, superior thalamic radiation, fornix, and cingulum, had significant negative associations with 1p/19q co-deletion (FDR = 4.72 × 10-5). These tracts are crucial in maintaining the integrity of brain networks. Differential analysis further supported these findings (FWER-corrected p < 0.05). The 1p/19q non-co-deletion group exhibited significantly higher clustering coefficients (FDR-corrected p < 0.05) and reduced betweenness centrality (FDR-corrected p < 0.05) in regions around the tumor compared to HC group. Graph theoretical analysis indicated that non-co-deletion patients had increased local clustering and decreased betweenness centrality in peritumoral brain regions compared to co-deletion patients and healthy controls (FDR-corrected p < 0.05). Additionally, despite not being significant through correction, patients with 1p/19q co-deletion exhibited lower trends in weighted average clustering coefficient, transitivity, small worldness, and global efficiency, while showing higher tendencies in weighted path length compared to patients without the co-deletion.
UNASSIGNED: The findings of this study underline the significant role of 1p/19q co-deletion in altering structural connectivity in insular glioma patients. These alterations in brain networks could have profound implications for the neural functionality in patients with dominant hemisphere insular gliomas.
摘要：
■本研究旨在阐明1p/19q共缺失对优势半球岛叶弥漫性神经胶质瘤患者结构连通性改变的影响。
■我们纳入了32例左侧岛叶胶质瘤和20例健康对照。用弥散MRI,我们应用了相关纤维束描记术，差分纤维束造影,和图论分析，探索与1p/19q共缺失相关的潜在连通性。
■研究表明，关键的深层内侧纤维束的定量各向异性（QA），包括前丘脑辐射,上丘脑辐射，穹窿,和扣带，与1p/19q共缺失呈显著负相关(FDR=4.72×10-5)。这些片段对于维持大脑网络的完整性至关重要。差异分析进一步支持这些发现(FWER校正的p<0.05)。与HC组相比,1p/19q非共缺失组在肿瘤周围区域中表现出显著更高的聚类系数(FDR校正的p<0.05)和降低的介数中心性(FDR校正的p<0.05)。图论分析表明，与共缺失患者和健康对照相比，非共缺失患者在瘤周大脑区域的局部聚集性增加，介数中心性降低（FDR校正的p<0.05）。此外,尽管通过修正并不重要，1p/19q共缺失患者的加权平均聚类系数呈较低趋势，传递性,小世界,和全球效率，与没有共缺失的患者相比，加权路径长度的趋势更高。
■这项研究的结果强调了1p/19q共缺失在改变岛叶胶质瘤患者结构连通性方面的重要作用。脑网络的这些改变可能对优势半球岛叶胶质瘤患者的神经功能具有深远的影响。
■我们纳入了32例左侧岛叶胶质瘤和20例健康对照。用弥散MRI,我们应用了相关纤维束描记术，差分纤维束造影,和图论分析，探索与1p/19q共缺失相关的潜在连通性。
■研究表明，关键的深层内侧纤维束的定量各向异性（QA），包括前丘脑辐射,上丘脑辐射，穹窿,和扣带，与1p/19q共缺失呈显著负相关(FDR=4.72×10-5)。这些片段对于维持大脑网络的完整性至关重要。差异分析进一步支持这些发现(FWER校正的p<0.05)。与HC组相比,1p/19q非共缺失组在肿瘤周围区域中表现出显著更高的聚类系数(FDR校正的p<0.05)和降低的介数中心性(FDR校正的p<0.05)。图论分析表明，与共缺失患者和健康对照相比，非共缺失患者在瘤周大脑区域的局部聚集性增加，介数中心性降低（FDR校正的p<0.05）。此外,尽管通过修正并不重要，1p/19q共缺失患者的加权平均聚类系数呈较低趋势，传递性,小世界,和全球效率，与没有共缺失的患者相比，加权路径长度的趋势更高。
■这项研究的结果强调了1p/19q共缺失在改变岛叶胶质瘤患者结构连通性方面的重要作用。脑网络的这些改变可能对优势半球岛叶胶质瘤患者的神经功能具有深远的影响。
