Abstract：
This study aimed to retrospectively evaluate the baseline and follow-up viral loads and viral clearance times in cases followed for asymptomatic and symptomatic congenital cytomegalovirus (cCMV) infection between August 2010 and August 2022. Among 93 cases, they had asymptomatic (n: 55) and symptomatic (n: 38). The median baseline blood viral load detected in the symptomatic cCMV (ScCMV) infection (13 054 IU/mL) was significantly higher than that of asymptomatic cCMV (AcCMV) infection (4636 IU/mL) (p < 0.013). There was no difference in median viral clearance times (75 and 90 days, respectively) in baseline viremic cases in the ScCMV and AcCMV infection groups. There were no differences in median baseline blood viral load (6930 IU/mL and 14 268 IU/mL, respectively) and median viral clearance times (75 and 85 days, respectively) between the 6-week and 6-month antiviral treatment group. No correlation was found between baseline blood viral load, clinical severity, and the number of systems involved. However, in initial viremic cases, the viral load threshold for a symptomatic case was 8856 IU/mL, with 85.7% sensitivity and 54.5% specificity.
摘要：
本研究旨在回顾性评估2010年8月至2022年8月期间无症状和有症状的先天性巨细胞病毒（cCMV）感染病例的基线和随访病毒载量和病毒清除时间。93例病例中,他们无症状(n:55)和有症状(n:38)。在有症状的cCMV（ScCMV）感染（13054IU/mL）中检测到的中位基线血液病毒载量显着高于无症状的cCMV（AcCMV）感染（4636IU/mL）（p<0.013）。中位病毒清除时间没有差异(75天和90天，分别）在ScCMV和AcCMV感染组的基线病毒血症病例中。中位基线血液病毒载量(6930IU/mL和14268IU/mL,分别)和中位病毒清除时间(75天和85天，分别）在6周和6个月抗病毒治疗组之间。基线血液病毒载量之间没有发现相关性，临床严重程度，以及涉及的系统数量。然而,在最初的病毒血症病例中，有症状病例的病毒载量阈值为8856IU/mL，敏感性为85.7%，特异性为54.5%。
