PDF(Pubmed)
Abstract：
BACKGROUND: Gastric cancer (GC), as a highly lethal malignancy, is the fourth most common malignancy and the second leading cause of cancer-related death worldwide. This study is an umbrella review of systematic reviews and meta-analyses to present an overview of the extent and reliability of the claimed association between physical activity and the likelihood of developing or dying from GC.
METHODS: This study was conducted following the Joanna Brigs Institute (JBI)\'s methods for conducting umbrella reviews. A systematic search was performed in PubMed, Scopus, Web of Science, and ProQuest databases until July, 2024 with predefined keywords. Two independent authors assessed the Risk of Bias in included studies using the JBI critical appraisal tool for the assessment of the quality of systematic reviews and disagreements between the authors were resolved through discussion or the opinion of another author.
RESULTS: Five systematic reviews were included in this analysis, offering a more comprehensive understanding of the inverse relationship between physical activity and gastric cancer risk. Compared to previous studies, this review provides stronger evidence that moderate-to-high levels of physical activity significantly reduce the overall risk of developing gastric cancer.
CONCLUSIONS: While a link between physical activity and reduced cancer risk is promising, further research is crucial to unravel the specific mechanisms at play and to quantify the impact of increased activity levels on cancer prevention. Based on the findings of this study, physical activity is found to be associated with a decreased risk of GC; however, the limitation of the evidence suggested a need for future studies on this topic.
METHODS: This study was conducted following the Joanna Brigs Institute (JBI)\'s methods for conducting umbrella reviews. A systematic search was performed in PubMed, Scopus, Web of Science, and ProQuest databases until July, 2024 with predefined keywords. Two independent authors assessed the Risk of Bias in included studies using the JBI critical appraisal tool for the assessment of the quality of systematic reviews and disagreements between the authors were resolved through discussion or the opinion of another author.
RESULTS: Five systematic reviews were included in this analysis, offering a more comprehensive understanding of the inverse relationship between physical activity and gastric cancer risk. Compared to previous studies, this review provides stronger evidence that moderate-to-high levels of physical activity significantly reduce the overall risk of developing gastric cancer.
CONCLUSIONS: While a link between physical activity and reduced cancer risk is promising, further research is crucial to unravel the specific mechanisms at play and to quantify the impact of increased activity levels on cancer prevention. Based on the findings of this study, physical activity is found to be associated with a decreased risk of GC; however, the limitation of the evidence suggested a need for future studies on this topic.
摘要：
背景：胃癌（GC），作为一种高度致命的恶性肿瘤，是全球第四大常见恶性肿瘤，也是癌症相关死亡的第二大原因。这项研究是对系统评价和荟萃分析的综述，旨在概述体力活动与GC发展或死亡的可能性之间的相关性的程度和可靠性。
方法：这项研究是按照JoannaBrigsInstitute（JBI）的方法进行的。在PubMed中进行了系统的搜索，Scopus,WebofScience,和ProQuest数据库，直到7月，2024与预定义的关键字。两名独立作者使用JBI批判性评估工具评估纳入研究的偏差风险，以评估系统评价的质量，作者之间的分歧通过讨论或另一位作者的意见得到解决。
结果：本分析包括五个系统综述，提供了更全面的了解体力活动与胃癌风险之间的反比关系。与以前的研究相比，本综述提供了更有力的证据,证明中等至高水平的体力活动可显著降低胃癌的总体风险.
结论：虽然体力活动和降低癌症风险之间的联系是有希望的，进一步的研究对于解开特定的作用机制和量化活动水平增加对癌症预防的影响至关重要.根据这项研究的结果，发现身体活动与GC风险降低有关；然而，证据的局限性表明需要对该主题进行进一步的研究.
方法：这项研究是按照JoannaBrigsInstitute（JBI）的方法进行的。在PubMed中进行了系统的搜索，Scopus,WebofScience,和ProQuest数据库，直到7月，2024与预定义的关键字。两名独立作者使用JBI批判性评估工具评估纳入研究的偏差风险，以评估系统评价的质量，作者之间的分歧通过讨论或另一位作者的意见得到解决。
结果：本分析包括五个系统综述，提供了更全面的了解体力活动与胃癌风险之间的反比关系。与以前的研究相比，本综述提供了更有力的证据,证明中等至高水平的体力活动可显著降低胃癌的总体风险.
结论：虽然体力活动和降低癌症风险之间的联系是有希望的，进一步的研究对于解开特定的作用机制和量化活动水平增加对癌症预防的影响至关重要.根据这项研究的结果，发现身体活动与GC风险降低有关；然而，证据的局限性表明需要对该主题进行进一步的研究.
