RESULTS: The survival rate was 16.7% in control and 33.3% in treatment groups. In the control group, mean arterial pressure dropped from 93.6 ± 8.6 to 75.5 ± 9.7 mmHg by 9 h, which was not affected by the combined therapy. Pulmonary dysfunction was not attenuated by the combined therapy either. The combined therapy had no effect on increased extravascular lung water content and fluid effusion into thoracic cavity. The bacterial number in the bronchoalveolar lavage fluid was significantly increased in the treatment group than the control group. The blood bacterial number remained comparable between groups.
CONCLUSIONS: Combined vitamin C, hydrocortisone, and thiamine did not attenuate severity of ovine sepsis.
结果:对照组生存率为16.7%,治疗组为33.3%。在对照组中,平均动脉压9小时从93.6±8.6下降到75.5±9.7mmHg,不受联合治疗的影响。联合治疗也未减轻肺功能障碍。联合治疗对增加血管外肺含水量和胸腔积液没有影响。治疗组支气管肺泡灌洗液中细菌数量明显高于对照组。各组之间的血液细菌数量保持相当。
结论:复合维生素C,氢化可的松,硫胺素并不能减轻绵羊脓毒症的严重程度。